DSC单峰法分析有机结晶物质纯度的评述

Determination of organic crystalline substances purity by DSC single-peak method

对测定有机结晶物质纯度的DSC单峰法进行了评述,从原理层面阐述了DSC法测定时被测样品的基本条件,分析了动态DSC测定法和上述基本条件衔接中存在的问题及在实践中DSC测定法的可靠性,探讨了在数据处理过程中存在的问题。陈群-顾浩经验公式综合考虑了样品整体熔化过程中热效应重叠的熔融吸热峰面积的再分配问题,避免了传统方法对熔化早期阶段无法确认而进行面积补偿带来的结果不准确性,可用于快速、准确测定有机结晶物质的纯度。

DSC single-peak method for determining the purity of organic crystalline substances is criticized.The basic conditions of the sample measured by DSC is expounded from the principal aspect.The problems in the connection between dynamic DSC determination and the basic conditions are analyzed,and the reliability of DSC determination method in practice is also explored.The problems in data processing are also probed.The Chen Qun-Gu Hao empirical formula comprehensively considers the redistribution problem of the area of the melting heat absorption peak with overlapping thermal effects during the whole melting process of the sample,which avoids the inaccuracy of the result caused by the area compensation which cannot be confirmed by the traditional methods in the early melting stage,and can be used to quickly and accurately determine the purity of organic crystalline substances.