肥大细胞与心血管疾病关系研究进展

Research Progress on the Relationship between Mast Cells and Cardiovascular Disease

肥大细胞作为骨髓系谱的免疫细胞,广泛分布于黏膜与结缔组织中。肥大细胞主要通过受体与其配体结合进行信号转导,调控肥大细胞活化并释放多种具有生物学效应的活性介质,进而参与机体免疫防御、血栓形成以及损伤修复与心肌重塑等生理病理过程。近年来,肥大细胞在心血管疾病中发挥的作用及致病机制成为新的研究热点。以肥大细胞及其介质为靶点的心血管疾病相关性研究已进入临床试验阶段。该文主要就肥大细胞在心血管疾病中的作用及其潜在的临床应用价值进行综述,以期为心血管疾病的相关治疗提供新思路。

As immune cells of the bone marrow lineage,mast cells are widely distributed in mucous membranes and connective tissues.Receptors on mast cells binding to their ligands,regulate the activation of mast cells and release a variety of active mediators with biological effects,thereby enable mast cells to participate in physiological and pathological processes such as immune defense,thrombosis,damage repair and myocardial remodeling.In recent years,the role and pathogenic mechanisms of mast cells in cardiovascular diseases have become new research hotspots.Research on cardiovascular related diseases targeting mast cells and their mediators has entered the clinical trial stage.This article mainly reviews the role of mast cells in cardiovascular diseases and their potential clinical application value,with a view to providing new ideas for the treatment of cardiovascular diseases.