细胞外囊泡RNA的多样性特征

Diversity Characteristics of Extracellular Vesicle RNA

细胞外囊泡是一类可携带蛋白质、核酸、脂质等内含物的新型细胞间通讯介质。可向邻近及远处细胞传递生物信息分子,调控受体细胞正常生理及病理发展过程。在肿瘤发生与发展、疾病的诊断治疗、细胞分子生物学研究等方面发挥着越来越重要的作用。作为基因表达的重要调节剂,RNA是细胞外囊泡中一类丰富的内含物,且细胞外囊泡RNA种类繁多,分布及分类水平不等,对其的研究极具挑战性。该文重点讨论细胞外囊泡RNA的多样性特征,由此回顾细胞外囊泡RNA的研究进展。

Extracellular vesicles are a new type of intercellular communicative medium that can carry proteins,nucleic acids,lipids and other inclusions.They can transmit biological informational molecules to adjacent and distant cells and regulate the normal physiological and pathological development of recipient cells.It plays an increasingly important role in tumorigenesis and development,diagnosis and treatment of diseases,and cellular molecular biology research.As an important regulator of gene expression,RNA is a kind of abundant inclusions in extracellular vesicles,and there are many kinds of extracellular vesicle RNAs,the levels of distribution and classification haven`t been established,which means that there will be a big challenge in this research.This article focuses on the diversity of extracellular vesicle RNA,and reviews the advances in extracellular vesicle RNA.