Irisin通过调控血管内皮细胞功能参与代谢性心血管疾病的研究进展

The Role of Irisin in Metabolic Cardiovascular Disease by Regulating the Function of Endothelial Cell

血管内皮细胞功能损伤是心血管病变的发病基础,血管内皮细胞的炎症、氧化应激、凋亡、增殖等与代谢性心血管疾病密切相关。Irisin作为新被发现的肌肉因子与糖脂代谢息息相关。近年来,Irisin在降脂以及糖尿病治疗方面已经受到广泛关注。同样,Irisin在代谢性心血管疾病方面的调控作用也开始引起关注,但Irisin在代谢性心血管疾病中的调控作用机制尚不明确。该综述将总结讨论Irisin来源、功能,并描述通过影响血管内皮细胞在代谢性心血管疾病中的调控及其作用机制,包括激活血管舒张信号通路、抑制血管内皮细胞氧化应激通路、减少血管内皮细胞炎症信号通路和活化血管内皮细胞增殖与迁移信号通路等,同时,提出了Irisin在临床应用中的前景。

Vascular endothelial cells dysfunction such as inflammation,apoptosis,oxidative stress and nitrification stress of endothelial cells is highly correlated with metabolic cardiovascular diseases.Irisin as a newly discovered myokine is closely related to glucose and lipid metabolism.In recent years,irisin has been widely concerned in the prevention and treatment of diabetes through regulating lipid metabolism.Meanwhile,the role of irisin in metabolic cardiovascular diseases has also gained extensive attention,but the regulatory role and underlying mechanism of irisin in metabolic cardiovascular diseases is not clear.In the review,we summarize the origin and function of irisin,and also investigate it’s role and the underlying mechanism in metabolic cardiovascular diseases by regulating the founction of endothelial cell,including the activation of diastolic vascular signaling pathway,the inhibition of oxidative stress pathway in vascular endothelial cells,the decrease of inflammatory signaling pathway in vascular endothelial cells and the promotion of the proliferation and migration of vascular endothelial cells,and so on.Finally,the prospects of irisin in clinical application have also been proposed.