摘要
近期的研究表明,在肌肉损伤或病变中,肌肉干细胞的活性与炎症反应有密切的关系。肌肉干细胞可以被参与炎症反应的多种免疫细胞及细胞因子调控,从而进行增殖或分化。该文概述了肌肉再生过程中炎症反应调控肌肉干细胞活性的研究进展,总结了肌肉损伤或病理条件下,炎症反应调控肌肉干细胞的分子和细胞机制。
Increasing amount of data from recent researches have revealed frequent crosstalk between muscle stem cells and inflammation.Proliferation and differentiation of muscle stem cells post muscle injury are closely correlated to the progress of inflammations occurred upon injury.This review will summarize the recent progress about the communications between muscle stem cells and immune cells involved in inflammation and the regulatory mechanism of cytokines on muscle stem cell behaviors during muscle regeneration.This will help us to further understand the tightly orchestrated muscle regeneration process.
作者
杨雯隽
刘欢
余阳
胡苹
Yang Wenjuan;Liu Huan;Yu Yang;Hu Ping(State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Innovation Center for Cell Signaling Network,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第S01期2209-2215,共7页
Chinese Journal of Cell Biology
基金
中国科学院器官重建与制造战略性先导科技专项(批准号:XDA16021400)
中国科学院青年科学创新促进会专项项目(批准号:2016246)
科技部重点研发计划(批准号:2017YFA002700)
国家自然科学基金(批准号:91649104、31671536)
上海市科学技术委员会NN-CAS基金(批准号:Y753S11802、18ZR1446300)资助的课题.
