尿毒症血液透析患者超敏C反应蛋白及铁参数联合检测的临床意义

Clinical Significance of Combined Detection of High-Sensitivity C-reactive Protein and Iron Parameters in Uremic Hemodialysis Patients

目的分析尿毒症血液透析患者超敏C反应蛋白(hs-CRP)和铁参数联合检测的价值。方法78例肾功能衰竭患者,根据hs-CRP测定值分为无微炎症组与有微炎症组,每组各39例,对比两组治疗前后各参数。结果两组患者治疗前后各指标具有明显差异(P<0.05),Hypo%与s TfR比治疗后高,其他指标都比治疗后低;治疗前,无微炎症组的TS、SI、SF比有微炎症组要低,s TfR比有微炎症组高(P<0.05);无微炎症组治疗后的参数变化幅度比有微炎症组要大(P<0.05)。结论尿毒症血液透析患者体内微炎症反应会对铁剂、EPO对肾性贫血的治疗效果造成影响,联合铁参数和超敏C反应蛋白能够对临床用药进行指导,其效果良好。

Objective This paper aims to analyze the value of combined detection of high-sensitivity C-reactive protein(hs CRP)and iron parameters in uremic hemodialysis patients.Methods 78 patients with renal failure who were divided into non micro inflammation group and micro inflammation group according to the measured hs CRP value,39 cases in each group.Results Before and after treatment,there were significant differences in each index between the two groups(P<0.05),Hyp%and s TfR were higher than those after treatment,and other indexes were lower than those after treatment;before treatment,TS,Si,SF of non micro inflammation group were lower than those of micro inflammation group,and s TfR was higher than that of micro inflammation group(P<0.05);the change range of parameters in non micro inflammation group after treatment was larger than that in micro inflammation group(P<0.05).Conclusion Microinflammatory reaction in uremic hemodialysis patients will affect the therapeutic effect of iron and EPO on renal anemia.The combination of iron parameters and high-sensitivity C-reactive protein can guide clinical medication,which effect is good.