体外膜氧合期间患者院内感染及抗生素临床应用管理的研究进展

Research progress in nosocomial infection and clinical management strategies of antibiotics during extracorporeal membrane oxygenation

体外膜氧合(ECMO)技术越来越多地用于难治性心肺衰竭的重症患者。ECMO期间获得性院内感染是最常见的并发症之一,严重威胁着患者临床预后。本文系统性综述ECMO患者发生院内感染时的感染源、临床管理策略及其抗生素干预指导方案与临床结局的关联,旨在正确认识ECMO治疗期间院内感染以及抗生素临床应用管理。

Extracorporeal membrane oxygenation(ECMO)is increasingly used in more and more patients with refractory cardiopulmonary failure.Nosocomial infection acquired during ECMO is one of the most common complications,which seriously threatens the clinical prognosis of patients.This article systematically reviewed the source of infection under ECMO treatment,clinical management strategies,and the relationship between antibiotic intervention guidelines and clinical outcomes in ECMO patients with nosocomial infection.Our purpose is to correctly recognize nosocomial infections during ECMO therapy and the management of clinical antibiotic application.