静息性心绞痛与血小板聚集

Silent Angina Pectoris and Platelet Aggregation

近年来认为缺血性心脏病发病与血小板聚集有关。研究资料表明,在心肌梗塞急性发作期间,血小板显著聚集,但心绞痛患者是否出现血小板聚集,文献的报导互不一致。本文对31例静息性心绞痛患者进行血小板聚集测定,观察此型患者与血小板聚集的关系。

It is generally held that abnormalities of platelet function plays an important role in the genesis or extension,or both,of myocrdial ischemia.Marked platelet aggregation has been described in acute attacks of myocardial infarction,while the existance of platelet aggregation in patients of angina pectoris is still uncertain.For investigation,we measured the circulating platelet aggregation(CPA)in vivo(Wu and Hoak’s method)and platelet aggregation threshold in vitro(Born’s method)simultaneously in 31 cases of angina pectoris at rest and in 33 healthy subjects as control.The result showed that the mean value of CPA of patients group was 0.92±0.05,which was obviously lower than the mean value 1.00±0.05(P<0.01)of the eontrol group and the average in vitro plaletet aggregation with collagen of the patients group was 52.56±9.96U versus 51.83±5.52U for the control group(P>0.05).Moreover,the mean value of CPA in severe cases of the patients group was 0.88±0.054 which was significantly lower than those of the light cases with mean value 0.95±0.04(P<0.01).Hence,our study demonstrated that platelet aggregation does occur in patients with angina peetoris at rest and that the level of CPA would be a better marker of isehemic heart disease.However it is not clearly known whether platelet aggergation induces the attack of angina peetoris at rest or the former is just provoked by myocardial ischemia.