荜铃胃痛颗粒联合盐酸伊托必利及艾司奥美拉唑治疗反流性食管炎的疗效观察

Clinical observation of Biling Weitong granule combined with itopride and esomeprazole in the treatment of reflux esophagitis

目的:评价荜铃胃痛颗粒联合盐酸伊托必利及艾司奥美拉唑治疗反流性食管炎的临床疗效。方法:选取反流性食管炎患者180例,采用随机、前瞻、自身对照分为A组(60例,荜铃胃痛颗粒+艾司奥美拉唑)、B组(60例,盐酸伊托必利+艾司奥美拉唑)、C组(60例,荜铃胃痛颗粒+盐酸伊托必利+艾司奥美拉唑),疗程均为8周。观察各组治疗前后患者临床症状改善情况。观察各组治疗前后内镜下食管黏膜炎症改善情况。结果:A、B、C组在临床症状方面的总有效率分别为80.00%(48/60)、76.67%(46/60)、93.33%(56/60),A组和C组比较、B组和C组比较,差异均有统计学意义(χ~2=4.615、6.536,P均<0.05),A、B组间比较差异无统计学意义(χ~2=0.196,P>0.05)。A、B、C组在内镜下食管黏膜炎症改善方面的总有效率分别为83.33%(50/60)、78.33%(47/60)、95.00%(57/60),A组和C组比较、B组和C组比较,差异均有统计学意义(χ~2=4.227、7.212,P均<0.05),A、B组间比较差异无统计学意义(χ~2=0.484,P>0.05)。结论:荜铃胃痛颗粒和盐酸伊托必利两者联合艾司奥美拉唑均可缓解反流性食管炎患者的临床症状,改善内镜组织学,三者联合用药疗效更佳。

Objective:To evaluate the clinical efficacy of Biling Weitong Granule combined with itopride and esomeprazole in the treatment of reflux esophagitis.Methods:180 patients with reflux esophagitis were randomly divided into group A(60 cases,Biling Weitong granule+esomeprazole),group B(60 cases,itopride+esomeprazole),group C(60 cases,Biling Weitong granule+itopride+eEsomeprazole).The course of treatment lasted 8 weeks.The improvement of clinical symptoms was observed before and after treatment.The improvement of endoscopic mucosal inflammation was observed before and after treatment.Results:The total effective rates of clinical symptoms in group A,B and C were 80.00%(48/60),76.67%(46/60)and 93.33%(56/60),respectively.There were significant differences between group A and C,group B and group C(χ~2=4.615、6.536,P<0.05).There was no significant difference between group A and B(χ~2=0.196,P>0.05).The total effective rates of improving esophageal mucosal inflammation in group A,B and C were 83.33%(50/60),78.33%(47/60)and 95.00%(57/60),respectively.There were significant differences between group A and C,as well as between group B and group C(χ~2=4.227、7.212,P<0.05).There was no significant difference between group A and B(χ~2=0.484,P>0.05).Conclusion:BilingWeitong granule combined with itopride and esomeprazole can alleviate the clinical symptoms of reflux esophagitis and improve endoscopic histology.The combination of the three drugs has a better curative effect.