2型糖尿病合并急性冠脉综合征患者血清脂联素及游离脂肪酸水平观察

Serum adiponectin and free fatty acid levels in patients with type 2 diabetes mellitus complicated with acute coronary syndrome

目的:探讨脂联素及游离脂肪酸与2型糖尿病合并急性冠脉综合征之间有无关联。方法:选取2型糖尿病合并急性冠脉综合征的住院患者入组(观察组,n=60),以及2型糖尿病组(无急性冠脉综合征的住院患者,n=60)、急性冠脉综合征组(无2型糖尿病的住院患者,n=60),以及正常对照组(无2型糖尿病及急性冠脉综合征的住院患者,n=60)。收集入组人员一般资料,采用ELISA法测定脂联素、游离脂肪酸浓度,同时通过冠脉造影结果计算患者冠脉硬化的Gensini积分。结果:观察组患者血清脂联素水平低于2型糖尿病组患者,低于急性冠脉综合征组患者,显著低于正常对照组。观察组患者游离脂肪酸水平高于急性冠脉综合征组患者,高于2型糖尿病组患者,显著高于正常对照组。脂联素水平与心肌肌钙蛋白Ⅰ、2型糖尿病、空腹血糖、HbA1c、总胆固醇、低密度脂蛋白胆固醇、游离脂肪酸、Gensini评分相关。游离脂肪酸与心肌肌钙蛋白Ⅰ、2型糖尿病、空腹血糖、HbA1c、总胆固醇、低密度脂蛋白胆固醇、脂联素、Gensini评分相关。结论:血清脂联素和游离脂肪酸含量与冠状动脉病变程度及血糖水平相关。

Objective:To investigate the correlation between adiponectin and free fatty acids and type 2 diabetes mellitus with acute coronary syndrome.Methods:Hospitalized patients with type 2 diabetes mellitus complicate with acute coronary syndrome(observation group,n=60),type 2 diabetes mellitus group(no acute coronary syndrome,n=60),acute coronary syndrome group(no type 2 diabetes mellitus,n=60),and normal control group(no type 2 diabetes mellitus and no acute coronary syndrome,n=60)were selected.General data of the enrolled subjects were collected and the concentrations of adiponectin and free fatty acids were determined by ELISA.Meanwhile,the Gensini score of coronary artery sclerosis was calculated by coronary angiography.Results:Serum adiponectin levels in the observation group were lower than those in the type 2 diabetes group,the acute coronary syndrome group and the normal control group.The free fatty acid level in the observation group was higher than that in the acute coronary syndrome group,higher than that in the type 2 diabetes group,and significantly higher than that in the normal control group.Adiponectin levels were associated with cardiac troponin I,type 2 diabetes,fasting glucose,Hb A1 c,total cholesterol,LDL cholesterol,free fatty acids,and Gensini scores.Free fatty acids were associated with cardiac troponin I,type 2 diabetes,fasting glucose,HbA1 c,total cholesterol,LDL cholesterol,adiponectin,and Gensini scores.Conclusion:Serum adiponectin and free fatty acid levels are correlated with coronary artery disease and blood glucose.