血清NGAL、Cys-C和RBP联合检测对早期肾损伤的诊断价值

The Value of Combined Detection of Serum NGAL,Cys-C,and RBP in the Early Diagnosis of Renal Injury

目的:分析血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、半胱氨酸蛋白酶抑制剂C(Cys-C)和尿视黄醇结合蛋白(RBP)的检测在早期肾损伤诊断中的价值。方法:选取2021年5月至2022年8月广东省中西医结合医院收治的47例早期肾损伤患者作为观察组,再选取同期40例健康体检者作为对照组。比较两组研究对象的血清NGAL、Cys-C和RBP水平,分析各指标的诊断价值,并分析肾损伤分级与NGAL、Cys-C、RBP的相关性。结果:观察组患者的血清NGAL、Cys-C和RBP水平均显著高于对照组,差异均具有统计学意义(P<0.05)。观察组患者的NGAL、Cys-C和RBP异常率均显著高于对照组,差异均具有统计学意义(P<0.05);经Spearman相关性分析,NGAL、Cys-C、RBP与肾损伤分级均呈正相关(r=0.759、0.683、0.711,P均<0.05)。结论:早期肾损伤患者的NGAL、Cys-C和RBP水平会显著升高,三项指标联合检测对患者的早期肾损伤诊断与治疗具有一定的指导作用。

Objective To analyze the value of serum neutrophil gelatinase-associated lipid transport protein(NGAL),cystatin C(Cys-C)and urinary retinol-binding protein(RBP)in the diagnosis of early renal injury.Methods 47 patients with early renal injury treated in Guangdong Province Integrated Traditional Chinese and Western Medicine Hospital from May 2021 to August 2022 were selected as an observation group,and 40 healthy subjects in the same period were selected as a control group.The levels of serum NGAL,Cys-C and RBP were compared between the two groups,the diagnostic value of each index was analyzed,and the correlation between renal injury grade and NGAL,Cys-C,RBP was analyzed.Results The levels of serum NGAL,Cys-C and RBP in the observation group were significantly higher than those in the control group.The abnormal rates of NGAL,Cys-C and RBP in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).There was a positive correlation between NGAL,Cys-C,RBP and the grade of renal injury by Spearman correlation analysis(r=0.759,0.683,0.711,P<0.05).Conclusion The levels of NGAL,Cys-C and RBP in patients with early renal injury will be significantly increased.The combined detection of the three indexes plays a guiding role in the diagnosis and treatment of early renal injury.