棕榈酸帕利哌酮注射液治疗社区精神分裂症患者的临床效果

Clinical Efficacy of Palmitic Acid Paliperidone Injection in the Treatment of Community Schizophrenia Patients

目的:分析应用棕榈酸帕利哌酮注射液治疗社区精神分裂症患者的疗效、安全性及对其社会功能的影响。方法:选取2021年3月至2022年6月中山市第三人民医院收治的生活在社区且纳入管理的80例精神分裂症患者,应用棕榈酸帕利哌酮注射液治疗,在入组时、入组后第8周、入组后0.5年、入组后1年进行简明精神病评定量表(BPRS)、修改版外显攻击行为量表(MOAS)、个人和社会功能量表(PSP)、临床总体印象-严重程度量表(CGI-S)、治疗伴发症状量表(TESS)等量表评估。结果:相较于入组时,入组后第8周、入组后0.5年、入组后1年患者BPRS、MOAS各维度评分均降低,差异具有统计学意义(P<0.05)。相较于入组时,入组后第8周、入组后0.5年、入组后1年患者PSP评分均升高,CGI-S评分均降低,差异具有统计学意义(P<0.05)。患者入组后0.5年、1年的TESS评分低于入组时,入组后1年的TESS评分低于入组后第8周,差异具有统计学意义(P<0.05)。结论:应用棕榈酸帕利哌酮注射液治疗社区精神分裂症患者的疗效确切,能减轻症状、攻击行为、疾病严重程度,且安全性较高,还能提升患者社会功能。

Objective To analyze the efficacy,safety,and social function of palmitic acid palipidone injection in the treatment of community schizophrenia patients.Methods A total of 80 patients with schizophrenia admitted to Zhongshan Third People's Hospital from March 2021 to June 2022,who lived in the community and were included in the management,were selected for treatment with palmitic acid paliperidone injection.At the time of enrollment,the 8 weeks after enrollment,6 months after enrollment,and 1 year after enrollment,the brief psychiatric rating scale(BPRS),the modified overt aggression scale(MOAS),and the personal and social performance scale(PSP),the clinical global impressions-severity(CGI-S),the treatment emergent symptom scale(TESS)were evaluated.Results Compared to the time of enrollment,the BPRS and MOAS scores of patients at 8 weeks,6 months,and 1 year after enrollment were decreased,with statistically significant difference(P<0.05).Compared to the time of enrollment,the PSP score of patients were increased at 8 weeks,6 months,and 1 year after enrollment,while the CGI-S score were decreased,with statistically significant difference(P<0.05).The TESS scores of patients at 0.5 and 1 year after enrollment were lower than those at the time of enrollment,and the TESS scores at 1 year after enrollment were lower than those at 8 weeks after enrollment,with statistically significant difference(P<0.05).Conclusion The application of palmitic acid paliperidone injection in the treatment of community schizophrenia patients has a definite therapeutic effect,which can alleviate symptoms,aggressive behavior,disease severity,and has high safety.It can also improve pationts'social function.