马来酸麦角新碱联合卡贝缩宫素对宫缩乏力产后出血的预防效果

Prophylactic Effect of Ergometrine Maleate Combined with Carbetocin on Postpartum Hemorrhage after Uterine Inertia

目的:探究联合应用马来酸麦角新碱与卡贝缩宫素对宫缩乏力所致产后出血的防治效果。方法:选择2020年1月至2022年3月于上饶市妇幼保健院分娩的产妇60例为观察对象,按随机原则分成对照组(30例)、观察组(30例)。对照组产后应用卡贝缩宫素治疗,观察组则应用马来酸麦角新碱与卡贝缩宫素联合治疗。观察并记录两组产妇的临床疗效、产后出血情况以及不良反应的发生率,比较两组产妇的产后2 h生命体征及产后出血量。结果:观察组的总治疗有效率(96.67%)较对照组(73.33%)更高,差异具有统计学意义(P<0.05);两组产妇产后2 h的心率、收缩压及舒张压比较,差异均无统计学意义(P>0.05);观察组产妇产后1 h、2 h、6 h及24 h的出血量较对照组均更少,差异均具有统计学意义(P<0.05);观察组产妇的产后出血的发生率(6.67%)较对照组(26.67%)更低,差异具有统计学意义(P<0.05);两组产妇用药不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:马来酸麦角新碱与卡贝缩宫素联合防治宫缩乏力产后出血的效果确切,能降低产妇产后出血量,减少产后出血发生率,且对产妇生命体征无显著干扰,用药不良反应少,治疗安全性相对较高。

Objective To explore the combined application of ergometrine maleate and carbetocin in the prevention and treatment of postpartum hemorrhage caused by uterine inertia.Methods 60 parturient women who gave birth in Shangrao Maternal and Child Health Hospital from January 2020 to March 2022 were selected as the observation objects,and were randomly divided into a control group and an observation group,with 30 cases in each group.The control group was treated with carbetocin postpartum,while the observation group was treated with ergometrine maleate combined with carbetocin.The clinical efficacy,postpartum bleeding and the incidence of adverse reactions were observed and recorded in the two groups.The postpartum vital signs and postpartum blood loss in 2 h were compared between the two groups.Results The total effective rate of the observation group was 96.67%,higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in heart rate,systolic blood pressure and diastolic blood pressure 2 h after delivery between the two groups(P>0.05).The amount of postpartum bleeding at 1 h,2 h,6 h and 24 h in the observation group were less than those in the control group,and the differences were statistically significant(P<0.05).The incidence of postpartum hemorrhage in the observation group was 6.67%,lower than 26.67%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion The combined effect of ergometrine maleate and carbetocin in the prevention and treatment of postpartum hemorrhage due to uterine inertia is exact,which can reduce postpartum hemorrhage and reduce the incidence of postpartum hemorrhage,and has no significant interference with maternal vital signs,less adverse drug reactions,and relatively high treatment safety.