平潭地区18000例农村妇女HPV检查结果分析

Analysis of HPV Examination Results of 18000 Rural Women in Pingtan Area

目的:分析平潭地区2020年1月至2022年3月期间18000例农村妇女人乳头状瘤病毒(HPV)感染情况,为宫颈癌筛查、HPV感染的防控及疫苗的开发提供参考依据。方法:回顾性分析平潭综合实验区妇幼保健院2020年1月至2022年3月初筛方法为HPV检测的18000例农村妇女的宫颈癌筛查数据,对检测结果进行统计分析。结果:HPV感染检出率为12.02%(2163/18000),其中高危型感染率构成比76.61%(1657/2163),低危型感染率构成比23.39%(506/2163),单一感染检出率11.04%(1987/18000),宫颈癌前病变检出率为644.4/10万(116/18000),宫颈癌检出率为50/10万(9/18000),宫颈癌早诊率为96.69%(117/121)。HPV基因分型检测型别为25种,包括高危型别19种,分别为HPV 16、55、52、53、18、31、33、39、56、59、66、68、51、35、45、58、82、73和83,位居前三名的是HPV 16(17.80%)、HPV 55(12.25%)和HPV 52(8.46%),低危型别6种,分别为HPV 6、11、44、43、81和42,低危型以HPV 6最多见(9.94%)。结论:平潭地区宫颈癌筛查妇女HPV感染状况、亚型分布存在一定的地域特点,以HPV检测为初筛方法对宫颈癌检查策略具有指导意义。

Objective To analyze the human papillomavirus(HPV)infection status of 18000 rural women in Pingtan area from January 2020 to March 2022,and to provide reference for cervical cancer screening,prevention and control of HPV infection and vaccine development.Methods The cervical cancer screening data of 18000 rural women whose primary screening method was HPV test in the Maternal and Child Health Hospital of Pingtan Comprehensive Experimental Area from January 2020 to March 2022were retrospectively analyzed,and the test results were statistically analyzed.Results The detection rate of HPV infection was 12.02%(2163/18000),the constituent ratio of high-risk HPV infection was 76.61%(1657/2163),the constituent ratio of low-risk HPV infection was 23.39%(506/2163),and the detection rate of single infection was 11.04%(1987/18000).The detection rate of cervical precancerous lesions was 644.4/100000(116/18000),the detection rate of cervical cancer was 50/100000(9/18000),and the early diagnosis rate of cervical cancer was 96.69%(117/121).There were 25 types of HPV genotyping detected,including 19 high-risk types,namely HPV16,55,52,53,18,31,33,39,56,59,66,68,51,35,45,58,82,73 and 83.The top three were HPV16(17.80%),HPV55(12.25%)and HPV52(8.46%).There were 6 low-risk genotypes,namely HPV6,11,44,43,81 and 42,and HPV6 was the most common low-risk genotype(9.94%).Conclusion There are geographical characteristics of HPV infection status and subtype distribution in cervical cancer screening women in Pingtan area.HPV detection as the primary screening method has guiding significance for cervical cancer screening strategy.