高流量呼吸湿化治疗仪对重症肺炎患者肺功能、血气指标及临床疗效的影响

Effect of High Flow Respiratory Humidification Therapeutic Apparatus on Pulmonary Function, Blood Gas Index and Clinial Efficacy in Patients with Severe Pneumonia

目的:探讨高流量呼吸湿化治疗仪对重症肺炎患者肺功能、血气指标及临床疗效的影响。方法:选取120例重症肺炎患者,均为2020年1月至2022年5月厦门大学附属中山医院接受治疗的患者,随机分为两组(观察组和对照组),各60例。两组患者均进行抗感染治疗,在此基础上对照组开展无创机械通气治疗,观察组应用高流量呼吸湿化治疗仪辅助吸氧。在两组患者治疗前、治疗后对各项治疗指标(血清炎症因子、肺通气功能、动脉血气分析及生活质量)展开比较,并比较组间总有效率、症状缓解时间、住院时间。结果:观察组总有效率相比于对照组更高。与对照组相比,观察组咳嗽、咳痰、气促等症状的缓解时间均更短,且住院时间也更短。在治疗后,相比于对照组的血清炎症因子各项指标的水平,观察组均更低。组间比较,观察组第1秒用力呼气量(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)、动脉血氧分压(PaO_(2))、氧合指数更高,而动脉血二氧化碳分压(PaCO_(2))更低。治疗后,生活质量评分组间比较,观察组中更高,差异均具有统计学意义(P<0.05)。结论:在重症肺炎患者的治疗中,应用高流量呼吸湿化治疗仪可减轻炎症反应、肺通气功能障碍及动脉血气紊乱,提升生活质量。

Objective To explore the effects of high flow respiratory humidification therapeutic apparatus on pneumonia function,blood gas indexes and clinical efficacy in patients with severe pneumonia.Methods A total of 120 patients with severe pneumonia who were treated in Zhongshan Hospital Affiliated to Xiamen University from January 2020 to May 2022 were randomly divided into an observation group and a control group,with 60 cases in each group.Patients in the two groups for anti-infection treatment.On this basis,the control group was treated with non-invasive mechanical ventilation,and the observation group used high flow respiratory humidification therapeutic apparatus for auxiliary oxygen inhalation,The treatment indicators(serum inflammatory factors,pulmonary ventilation function,arterial blood gas analysis and quality of life)were compared between the two groups before and after treatment,and the total effective rate,symptom relief time and hospitalization time were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group.Compared with the control group,the relief time of cough,expectoration,shortness of breath and other symptoms in the observation group was shorter,and the length of hospitalization time was shorter.After treatment,the levels of serum inflammatory factors in the observation group were lower than those in the control group.Comparison among groups,the forced expiratory volume in the first second(FEV1),forced expiratory volume in the first second/forced vital capacity ratio(FEV1/FVC),arterial partial pressure of oxygen(PaO_(2))and oxygenation index in the observation group were higher,while partial pressure of carbon dioxide(PaCO_(2))in the observation group was lower.After treatment,the quality of life score in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion In patients with severe pneumonia,high flow breathing humidification therapeutic instrument can reduce inflammatory response,pulmonary ventilation dysfunction and arterial blood gas disorder,and improve the quality of life.