福州地区健康人群血清25-羟维生素D参考区间的建立

Establishment of Reference Interval of Serum 25-hydroxy Vitamin D in Healthy People in Fuzhou Area

目的:建立福州地区表观健康人群血清25-羟维生素D[25(OH)D]参考区间,并分析不同性别间、不同年龄间血清25(OH)D的差异。方法:选取2016年1月至2021年1月在福建医科大学附属协和医院体检的401例健康人群,采用电化学发光法检测血清25(OH)D水平,进行统计学分析,建立参考区间。结果:本研究建立的血清25(OH)D参考区间为12.30~44.87 ng·mL^(-1);以性别分组,男性的血清25(OH)D浓度高于女性,差异具有统计学意义(P<0.05);以年龄分组,30~39岁组和40~49岁组间血清25(OH)D浓度差异无统计学意义(P>0.05),其余组间比较显示年龄分组间差异具有统计学意义(P<0.05)。结论:本研究建立的福州地区健康人群血清25(OH)D参考区间为12.30~44.87 ng·mL^(-1),血清25(OH)D水平与性别、年龄有相关性,男性高于女性,随年龄增长呈增高趋势。

Objective To establish the reference interval of serum 25-hydroxy vitamin D[25(OH)D]in apparent healthy people in Fuzhou area,and analyze the difference of serum 25(OH)D between different genders and ages.Methods A total of 401 healthy people who underwent physical examination in Union Hospital Affiliated to Fujian Medical University from January 2016 to January 2021 were selected.The level of serum 25(OH)D was detected by electrochemiluminescence method.Statistical analysis was performed to establish reference intervals.Results The reference interval of serum 25(OH)D established in this study was 12.30-44.87 ng·mL^(-1).Grouped by gender,the serum 25(OH)D concentration of males was higher than that of females,the difference was statistically significant(P<0.05).Grouped by age,there was no significant difference in serum 25(OH)D concentration between 30-39 years old and 40-49 years old group(P>0.05),while the difference between the age among other groups was statistically significant(P<0.05).Conclusion The reference interval of serum 25(OH)D for healthy people in Fuzhou area established in this study was 12.30-44.87 ng·mL^(-1).The level of serum 25(OH)D was related to gender and age.The level of serum 25(OH)D was higher in men than in women and increased with age.