薄氏腹针治疗晚期非小细胞肺癌的疗效及异常糖链糖蛋白变化情况观察

Observation on the Therapeutic Effect of Bo’s Abdominal Acupuncture on Late Non-Small-Cell Lung Carcinoma and the Change of Abnormal Glycoproteins

目的探讨薄氏腹针治疗晚期非小细胞肺癌的疗效以及观察异常糖链糖蛋白的变化情况。方法选取医院于2019年9月—2021年9月收治的晚期非小细胞肺癌患者60例,按照随机数字表法分为对照组30例与观察组30例。对照组采用常规药物治疗,观察组在对照组治疗的基础上,给予薄氏腹针治疗。观察比较两组患者治疗后肿瘤标志物[癌胚抗原(Carcinoembryonic Antigen,CEA)、神经元特异性烯醇化酶(Neuronal-specific enolase,NSE)、细胞角蛋白片段19抗原21-1(CYFRA21-1)]、异常糖链糖蛋白(Tumor abnormal protein,TAP)水平[TAP浓度(凝聚物面积)、TAP阳性率]、治疗总有效率和总稳定率。结果两组患者肿瘤标志物的比较,治疗前CEA、NSE、CYFRA21-1比较无明显差异(P>0.05),治疗后均降低(P<0.05),且观察组均低于对照组(P<0.05);TAP凝聚面积的比较,治疗后观察组TAP凝聚面积明显低于对照组(P<0.05);治疗总有效率的比较,治疗后观察组总有效率为66.67%,对照组为53.33%,观察组明显高于对照组(P<0.05);治疗总稳定率的比较,治疗后观察组总稳定率为86.67%,对照组为60.00%,观察组明显高于对照组(P<0.05)。结论薄氏腹针以扶正补虚代表穴位组合“引气归元”法为干预手段能改善“虚证”晚期非小细胞肺癌患者的生活质量,并且能够提高患者的免疫力以抵御病情肿瘤,改善预后,具有很好的临床疗效。

Objective To investigate the effect of bo’s abdominal acupuncture on advanced non-small cell lung cancer(NSCLC)and observe the changes of abnormal glycochain glycoprotein.Methods A total of 60 patients with advanced non-small cell lung cancer admitted to our hospital from September 2019 to September 2021 were selected and divided into control group(n=30)and observation group(n=30)according to the random number table method.The control group was treated with conventional drugs,and the observation group was treated with Bo’s abdominal acupuncture on the basis of the control group.Tumor markers[Carcinoembryonic Antigen(CEA),neuron-specific enolase(neuronal-specific enolase)were observed and compared between the two groups after treatment.NSE),cytokeratin fragment 19 antigen 21-1(CYFRA21-1)],Tumor abnormal protein(TAP)level[TAP concentration(area of aggregates),positive rate of TAP],overall effective rate and overall stability rate of treatment.Results There were no significant differences in tumor markers of CEA,NSE and CYFRA21-1 between the two groups before treatment(P>0.05),However,the difference in efficacy between the two groups was statistically significant(P<0.05),and the difference between the two groups was statistically significant(P<0.05).The area of TAP agglutination decreased significantly after treatment(P<0.05).After treatment,the total effective rates of the observation group and the control group were 66.67%and 53.33%,respectively(P<0.05).After treatment,the stability of the observation group and the control group were 86.67%and 60.00%,respectively,compared with the control group,the difference was statistically significant(P<0.05).Conclusion Boshi abdominal acupuncture can improve the quality of life of patients with"deficiency syndrome"advanced NON-small cell lung cancer,and improve the immunity of patients to resist tumor,improve prognosis,and has a good clinical effect.