活血养阴汤治疗糖尿病合并动脉粥样硬化的临床疗效观察

Clinical Curative Effect of Huoxue Yangyin Decoction(活血养阴汤)on Diabetes Mellitus Ccombined with Atherosclerosis

目的探讨活血养阴汤联合阿托伐他汀治疗糖尿病合并动脉粥样硬化的临床疗效及其对胰岛功能、血脂、血液流变学的影响。方法选取医院2018年3月—2021年3月收治的糖尿病合并动脉粥样硬化患者75例,采用随机数表法分为对照组37例和观察组38例,两组患者均给予常规治疗,对照组在常规治疗基础上给予阿司匹林+阿托伐他汀治疗,观察组患者在对照组基础上加用活血养阴汤治疗。比较两组患者临床疗效、治疗前后胰岛素指标变化情况、治疗前后血脂水平、治疗前后血液流变学情况及不良反应。结果治疗后观察组总有效率为97.37%(37/38),明显高于对照组的83.78%(31/38)(P<0.05);治疗后两组患者胰岛素功能指标明显优于治疗前,观察组空腹胰岛素(FINS),胰岛素抵抗(HOAM-IR)均明显低于对照组(P<0.05);观察组胰岛素B细胞基础功能(HOAM-α)水平明显高于对照组(P<0.05);治疗后两组患者血脂水平明显优于治疗前,观察组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白固醇(LDL-C)水平明显低于对照组,高密度脂蛋白固醇(HDL-C)水平明显高于对照组(P<0.05);治疗后两组患者血液流变学情况明显优于治疗前,观察组全血低切黏度、全血高切黏度、血浆比黏度、纤维蛋白原水平均明显低于对照组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论活血养阴汤辅助西医治疗糖尿病合并动脉粥样硬化疗效显著,可有效改善患者血脂水平和血液流变学,保护肾功能。

Objectixe To explore the clinical curative ffct of Huoxue Y:angyin Decoction(活血养阴汤)。combined with ator-vastatin on diabetes mellitus combined with satherosclerosis and its influences on islet function,blood lipid and hemorheology.Methods A total of 75 patients with diabetes mellitus and athersclerosis admitted to the hospital were enrolled between March 2018 and March 2021.They were divided into control goup(37 cases)and observation group(38 cases)by randorm number ta-ble method.On the basis of routine treatments,the control group was treated with aspirin and storvastatin,while the observation group was treated with Huoxue Yangyin Decoction on the basis of the control group.The clinical curative efect.,changes of insu-lin indexes,blood lipid and hemorheology before and after treatment and adverse reactions were compared between the two groups.Results After treatment,the total response rate in the observation group was significantly higher than that in the control group(97.37%ts 83.78%)(P<0.05).After treatment,insulin function indexes were significantly improved in both groups.The fasting insulin(FINS)and homostasis model assessment of insulin resistance(H0AM-IR)in the observation group were significantly lower than those in the control group(P<0.05),while the basic function of islet B cells(HOAM-β)was signifi-cantly higher than that in the control group(P<0.05).After treatment,the levels of blood lipid were significantly improved in both groups.The levels of total cholesterol(TC),triglyceride(TG)and low-density lipprotein cholesterol(LDL-C)in the ob-servation group were significantly lower than those in the control group,while the level of high-density lipoprotein cholesterol(HDL-C)was significantly higher than that in the control group(P<0.05).After treatment,the hemorheology in both groups was significantly improved.The whole blood low-shear viscosity,whole blood high-shear viscosity,plasma viscosity and fibrin-ogen in the oberation group were signifcantly lower than those in the control group(P<0.05).There was no signifcent difer-ence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative fect of western medi-cine assisted with Huoxue Y angyin Decoction is significant on diabetes mellitus combined with atherosclerosis,which can effec-tively improve blood lipid and hemorheology,and protect renal function.