孕期抑郁与妊娠期糖尿病发病风险关系的meta分析

Relationship between depression during pregnancyand the risk of gestational diabetes mellitus: a meta-analysis

目的系统评价孕期抑郁与妊娠期糖尿病发病风险之间的关系。方法检索Web of Science、PubMed、CBM、CNKI、万方及维普数据库中关于孕期抑郁与妊娠期糖尿病关系的研究,检索时限为建库至2021年12月25日。进行纳入文献的资料提取、质量评价。采用Stata16.0软件进行分析。结果共纳入7项队列研究,共含13139名孕妇。meta分析结果显示孕期抑郁可增加妊娠期糖尿病发病风险(OR=1.412,95%CI:1.186~1.682)。亚组分析进一步提示,研究国家[美国(OR=1.728,95%CI:1.276~2.338)、澳大利亚(OR=1.850,95%CI:1.140~3.001)]、研究类型[前瞻性研究(OR=1.356,95%CI:1.124~1.636)、回顾性研究(OR=1.850,95%CI:1.140~3.001)]、是否校正BMI[是(OR=1.379,95%CI:1.138~1.671)、否(OR=1.580,95%CI:1.040~2.400)]、糖尿病诊断方式[未描述(OR=1.639,95%CI:1.288~2.085)]、抑郁评估工具[CES-D(OR=1.570,95%CI:1.082~2.277)、EPDS(OR=1.621,95%CI:1.047~2.508)、HAD(OR=1.580,95%CI:1.040~2.400)]中孕期抑郁均可增加妊娠期糖尿病发生风险。结论孕期抑郁与妊娠期糖尿病发生风险增加有关。

Objective To systematically assess the relationship of depression during pregnancy with the risk of gestational diabetes mellitus.Methods We electronically searched databases including Web of Science,PubMed,CBM,CNKI,WanFang and VIP for published studies on the relationship between depression during pregnancy and gestational diabetes mellitus from the inception to December 25,2021.Data of the included literatures were extracted,and the quality was evaluated.Stata16.0 software was used for the analysis.Results Seven cohort studies were included,with a total of 13,139 pregnant women.Meta-analysis results revealed that depression during pregnancy could increase the risk of gestational diabetes mellitus(OR=1.412,95%CI:1.186-1.682).Subgroup analysis indicated that depression during pregnancy could increase the risk of gestational diabetes mellitus under countries with studies(America(OR=1.728,95%CI:1.276-2.338),Australia(OR=1.850,95%CI:1.140-3.001)),research design(prospective analysis(OR=1.356,95%CI:1.124-1.636),retrospective analysis(OR=1.850,95%CI:1.140-3.001)),BMI adjustment(yes(OR=1.379,95%CI:1.138-1.671),no(OR=1.580,95%CI:1.040-2.400)),diabetes diagnosis(not available(OR=1.639,95%CI:1.288-2.085)),and depression assessment tools(CES-D(OR=1.570,95%CI:1.082-2.277),EPDS(OR=1.621,95%CI:1.047-2.508),HAD(OR=1.580,95%CI:1.040-2.400)).Conclusion Depression during pregnancy is related with an increased risk of gestational diabetes mellitus.