中性粒细胞胞外诱捕网在脓毒症中的作用及药物治疗研究

Research progress on the function of neutrophil extracellular traps in sepsis and drug therapy

脓毒症是由于感染引起宿主反应失调,导致器官功能障碍的临床综合征。中性粒细胞胞外诱捕网(NETs)最初被认为是参与新的宿主防御机制形成的特殊物质,NETs在脓毒症中持续过度产生,可引起血管病变及其炎症激活。NETs可能成为脓毒症的免疫治疗新的研究靶点。本文就NETs在脓毒症中的病理生理学机制及潜在药物治疗的研究作重点阐述。

Sepsis is a clinical syndrome of organ dysfunction due to host response disorder caused by infection.Neutrophil extracellular trapping(NETs)were initially thought to be specific agents involved in the formation of new host defense mechanisms.NETs are consistently overproduced in sepsis,causing vascular lesions and their inflammatory activation.NETs may be a new immunotherapeutic target for sepsis.This review reviews the pathophysiological mechanism of NETs in sepsis and its potential drug therapy.