程序性细胞死亡蛋白-1抑制剂不良反应的热点分析

Hot spot analysis of adverse reactions of programmed cell death protein-1 inhibitors based on literature research

目的分析程序性细胞死亡蛋白-1抑制剂(programmed cell death receptor 1,PD-1)药物不良反应的研究热点,了解该领域发展现状并为未来研究提供方向和参考。方法以PubMed数据库中收录的关于PD-1抑制剂的药物不良反应文献为来源,以“antineoplastic agents,immunological/adverse effects”[Mesh]and“programmed cell death 1 receptor/antagonists and inhibitors”[Mesh]为检索策略,以2010-2020年为限定时间。采用书目共现分析系统软件抽取主要主题词/副主题词,获得高频主题词论文矩阵,利用gCLUTO软件对其进行聚类分析。结果检索得到411篇文献,20个高频主题词,可视化分析后得到联合治疗、非小细胞肺癌、黑色素瘤和疗法比较4个聚类。结论皮炎是程序性细胞死亡蛋白-1抑制剂较常见的不良反应,非小细胞肺癌患和晚期黑色素瘤为在抗PD-1治疗上最常被研究的肿瘤类型,Nivolumab是最常被研究的PD-1抑制剂类药物,对相关科学研究有一定帮助。

Objective In order to analyze the research hotspots of adverse reactions of programmed cell death protein-1 inhibitors,understand the development status of this field and provide direction and reference for future research.Methods This paper takes the literatures about adverse reactions of programmed cell death protein-1 inhibitors in PubMed database as the source literature,and uses bibliographic co-occurrence analysis software to count the main subject headings in the literature.The frequency of subject words and high-frequency words were intercepted to obtain the high-frequency subject words thesis matrix.The clustering software was used to cluster them to analyze the research hotspots of adverse reactions of programmed cell death protein-1 inhibitors.Results 411 related articles were detected,20 high-frequency keywords were obtained,and finally 4 research hotspots were obtained.Conclusion The analysis of the 4 research hotspots will lay a foundation for grasping the research status and development trend of adverse reactions of programmed cell death protein-1 inhibitors,and will be helpful to the relevant scientific research of professionals.