摘要
盐酸异丙嗪针对皮肤、耳鼻喉与内科疾病均具有良好作用,因此在临床儿科中应用较为广泛,由于该药规格较大,在临床儿童用药应用中受到一定限制。盐酸异丙嗪片含量过高极易引起不良反应,因此需分析盐酸异丙嗪片的含量,以便对用药偏差进行调整。高效液相色谱法能够结合药物动力学实现对药物实际含量的分析,凭借其高敏感性、特异性等优势,在近年药物分析中具有广泛应。高效液相色谱法以药物的应用范围为准,形成完善的色谱药物分析方案,及时对色谱色相变化进行调整,并进行科学评估,增强分离效果,准确测定药物含量,以优化高效液相法分析中药物成分的应用。本次研究主要对高效液相法测定儿童用药盐酸异丙嗪片含量研究进行综述,以期为儿科临床合理用药提供参考。
Promethazine hydrochloride has good effects on skin,ear,nose,and throat,as well as internal medicine diseases.Therefore,it is widely used in clinical pediatrics.Due to its large size,the use of this drug in clinical pediatric medicine is limited to some extent.Excessive content of promethazine hydrochloride tablets can easily cause adverse reactions,so it is necessary to analyze the content of promethazine hydrochloride tablets in order to adjust the medication deviation.High performance liquid chromatography can combine pharmacokinetics to analyze the actual content of drugs.With its advantages of high sensitivity and specificity,it has been widely applied in drug analysis in recent years.High performance liquid chromatography is based on the application scope of drugs,forming a comprehensive chromatographic drug analysis plan,timely adjusting chromatographic phase changes,and conducting scientific evaluations to enhance separation efficiency and accurately determine drug content,in order to optimize the application of drug components in high-performance liquid chromatography analysis.This study mainly reviews the research on the determination of the content of promethazine hydrochloride tablets in children's medication by high-performance liquid chromatography,in order to provide reference for the rational use of drugs in pediatric clinical practice.
作者
赵雪娜
孙晶
ZHAO Xue-Na;SUN Jing(Jinchang Drug Inspection and Testing Center,Jinchang 737100,China;Jinchang Central Hospital,Jinchang 737100,China)
出处
《实验室检测》
2024年第4期40-44,共5页
Laboratory Testing
基金
一般科技计划-青年人才基金类,项目名称:儿科用药异丙嗪手工分量法可行性研究,项目编号:2023RC004
关键词
高效液相色谱法
盐酸异丙嗪
儿童用药
含量测定
high performance liquid chromatography
promethazine hydrochloride
children's medication
content determination