抗栓泵联合中医疗法治疗绝经期妇女盆腔术后下肢静脉血栓的效果观察

Effect of antithrombotic pump combined with traditional Chinese medicine therapy on lower extremity venous thrombosis after pelvic surgery in menopausal women

目的研究抗栓泵联合中医疗法治疗绝经后妇女盆腔术后下肢静脉血栓患者的效果。方法选取2018年6月—2019年1月在宁波大学医学院附属医院收治的盆腔术后患有下肢静脉血栓的患者100例,按随机数字表法分为对照组和联合组各50例。对照组患者采用抗栓泵治疗,联合组患者在对照组的基础上联合中医疗法治疗。对2组患者治疗前后双下肢静脉血流速度、凝血功能指标凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)、凝血酶时间(TT)、D-二聚体(D-dimer)水平进行检测及中医症候进行评分,评价2组治疗效果及深静脉血栓形成率、并发症发生率,并做组间比较。结果治疗前2组患者右股、左股静脉血流速度、PT、APTT、FIB、TT、D-dimer水平、中医症候评分比较,差异无统计学意义(均P>0.05);治疗后联合组患者右股、左股静脉血流速度均快于对照组(均P<0.05)。治疗后联合组PT、APTT、TT时间长于对照组,FIB、D-dimer水平、中医症候评分低于对照组(均P<0.05)。联合组患者的治疗总有效率高于对照组(P<0.05)。联合组和对照组患者并发症发生率比较,差异无统计学意义(P>0.05)。结论抗栓泵联合中医疗法可改善绝经后妇女盆腔术后下肢静脉血栓患者凝血功能和双下肢静脉血流速度,减轻患者症状,临床疗效较好。

Objective To study the effect of antithrombotic pump combined with traditional Chinese medicine(TCM)in the treatment of lower extremity venous thrombosis in postmenopausal women after pelvic surgery.Methods One hundred patients with lower extremity venous thrombosis after pelvic surgery in our hospital from June 2018 to January 2019 were divided into control group and combined group with 50 cases each according to the random number table method.The patients in the control group were treated with antithrombotic pump,while the patients in the combined group were treated with TCM on the basis of the control group.The venous blood flow velocity,prothrombin time(PT),activated partial thromboplastin time(APTT),plasma fibrinogen(FIB),thrombin time(TT),D-dimer(D-dimer)of two groups were measured,and the symptoms of TCM were evaluated.The therapeutic effect,the rate of deep vein thrombosis and complications were evaluated and compared between the two groups.Results There were no significant difference in blood flow velocity,PT,APTT,FIB,TT,D-dimer level and TCM symptom score between the two groups before treatment(all P>0.05).After treatment,the blood flow velocity of right and left femoral vein in the combined group were faster than that of the control group(all P<0.05).The PT,APTT,TT time in the combined group were longer than that in the control group,the FIB,D-dimer level and TCM symptom score were lower than those in the control group(all P<0.05).The total effective rate of the combined group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of complications between two groups(P>0.05).Conclusion Antithrombotic pump combined with TCM therapy can improve the coagulation function and venous blood flow velocity of lower extremities in postmenopausal women with lower extremity venous thrombosis after pelvic surgery,alleviate the symptoms of patients,and have a good clinical effect.