手性磷酸催化的不对称转移氢化反应及磷酸硼烷的应用

Chiral Phosphoric Acid Catalyzed Asymmetric Transfer Hydrogenation and Application of Boro-Phosphate

不对称转移氢化反应作为还原反应中的重要组成部分被广泛应用于各类化合物、药物的研究与工业生产中。转移氢化反应最显著的特点是通过有机含氢化合物作为氢供体,避免了危险系数较高的氢气的使用。当前,在不对称转移氢化反应中应用最广泛的有机催化剂当属手性磷酸催化剂。综述了手性磷酸催化在不对称转移氢化反应中的最新进展,同时系统阐述了近几年硼烷作为氢供体形成的磷酸硼烷催化体系及其参与的不对称转移氢化反应。

Asymmetric transfer hydrogenation,as one primary section of reduction reaction,has been widely used and developed both in laboratory and industry.The main characteristic of asymmetric transfer hydrogenation is to utilize organic compounds as hydrogen source instead of hazardous H2 gas.Chiral phosphoric acids are most extensively used organic catalyst in asymmetric transfer hydrogenation.In this paper,recent development of asymmetric transfer hydrogenation with chiral phosphoric acids was described,and a new system of boro-phosphate with borane as hydrogen source was introduced as well as related asymmetric transfer hydrogenation reactions.