摘要
以4-甲基吡啶为起始原料,经硝化、还原、氯化三步反应合成了医药中间体2-氯-3-氨基-4-甲基吡啶,总收率为68.3%,较原有的4-甲基吡啶缩减了合成步骤,收率提升了11%。
Using 4-methyl pyridine as the starting material,pharmaceutical intermediate 2-chloro-3-amino-4-methyl pyridine was synthesized via three steps of nitration,reduction and chlorination,the overall yield was 68.3%.Compared with the original process,the synthesis steps were decreased,and the yield was increased by 11%.
作者
徐红纳
才玉婷
靳立国
张朝立
XU Hong-na;CAI Yu-ting;JIN Li-guo;ZHANG Zhao-li(Mudanjiang Medical College,Mudanjiang Heilongjiang 157011,China;Heilongjiang No.1 Geological Exploration Institute,Mudanjiang Heilongjiang 157011,China)
出处
《当代化工》
CAS
2020年第7期1277-1280,共4页
Contemporary Chemical Industry
基金
黑龙江省自然科学基金(项目编号:H2016092)
黑龙江省省属高等学校基本科研业务费科研项目(项目编号:2017-KYYWFMY-0657)