医药中间体2-氯-3-氨基-4-甲基吡啶的合成研究

Study on Synthesis of 2-Chlorine-3-amino-4-methyl Pyridine

以4-甲基吡啶为起始原料,经硝化、还原、氯化三步反应合成了医药中间体2-氯-3-氨基-4-甲基吡啶,总收率为68.3%,较原有的4-甲基吡啶缩减了合成步骤,收率提升了11%。

Using 4-methyl pyridine as the starting material,pharmaceutical intermediate 2-chloro-3-amino-4-methyl pyridine was synthesized via three steps of nitration,reduction and chlorination,the overall yield was 68.3%.Compared with the original process,the synthesis steps were decreased,and the yield was increased by 11%.