杜鹃兰酮的制备方法研究

Study on Preparation of Cremastranone

为了探究抗糖尿病性视网膜病变活性天然产物杜鹃兰酮的制备工艺,本研究以市售可得的4-苄氧基-6-羟基-2,3-二甲氧基苯乙酮为原料,经缩合、氢化、苄基化及选择性去甲基化等6步反应,以9.6%的总收率制备了杜鹃兰酮。最后考察了选择性去甲基化反应中反应溶剂、反应温度对目标产物得率的影响。

In order to explore the preparation process of cremastranone,a natural product of anti-diabetic retinopathy activity,cremastranone was prepared with 4-oxyoxanoe-6-hydroxy-2,3-dioxybenzone as raw material via six-step reactions,such as condensation,hydrogenation,benzylation,selective demethylation and so on,and the total yield was 9.6%.The effect of reaction solvent and reaction temperature on the yield of the target product was also investigated in the selective demethylation reaction.