摘要
为了探究抗糖尿病性视网膜病变活性天然产物杜鹃兰酮的制备工艺,本研究以市售可得的4-苄氧基-6-羟基-2,3-二甲氧基苯乙酮为原料,经缩合、氢化、苄基化及选择性去甲基化等6步反应,以9.6%的总收率制备了杜鹃兰酮。最后考察了选择性去甲基化反应中反应溶剂、反应温度对目标产物得率的影响。
In order to explore the preparation process of cremastranone,a natural product of anti-diabetic retinopathy activity,cremastranone was prepared with 4-oxyoxanoe-6-hydroxy-2,3-dioxybenzone as raw material via six-step reactions,such as condensation,hydrogenation,benzylation,selective demethylation and so on,and the total yield was 9.6%.The effect of reaction solvent and reaction temperature on the yield of the target product was also investigated in the selective demethylation reaction.
作者
陈卓
谭李玉
杨月
乌雪娟
夏锐
CHEN Zhuo;TAN Li-yu;YANG Yue;WU Xue-juan;XIA Rui(Xi’an Medical University,Xi’an Shaanxi 710021,China)
出处
《当代化工》
CAS
2020年第7期1265-1268,共4页
Contemporary Chemical Industry
基金
陕西省教育厅专项科研计划项目(项目编号:19JK0772)
西安医学院大学生创新创业训练计划项目(项目编号:2018DC-32,2018DC-75)
关键词
杜鹃兰酮
选择性去甲基化反应
高异黄酮
Cremastranone
Selective demethylation reaction
Homoisoflavonoids