绿色加氢合成新戊二醇的一锅法合成

One-pot Synthesis of Neopentyl Glycol by Green Hydrogenation Process

为了解决目前新戊二醇反应废水量大问题,采用异丁醛、甲醛为原料在高压釜内,在三乙胺催化下缩合合成了羟基新戊醛,进一步在钯碳催化下,与氢气、甲醇反应一锅法合成了新戊二醇(NPG),系统地研究了不同反应条件对新戊二醇收率和选择性的影响。结果表明最佳缩合工艺条件为:n(异丁醛)∶n(甲醛)=1∶1.05,三乙胺加入量7%,反应温度60℃,反应时间5h;最佳加氢工艺条件为:反应压力4MPa,反应温度95℃,反应时间4h时,NPG收率为94.6%,NPG选择性为94.7%。本工艺路线合成新戊二醇废水量是传统歧化法路线废水量1/3左右,具有工业化前景。

In order to solve the problem of producing large amount of wastewater in synthesis of neopentyl glycol by current process,using isobutyl aldehyde and formaldehyde as raw materials,hydroxypivalaldehyde was synthesized in the autoclave by condensation reaction with triethylamine as catalyst,and then the hydroxypivalaldehyde reacted with hydrogen and methanol to synthesize neopentyl glycol by one pot method with palladium-carbon catalyst.The effect of different reaction conditions on the yield and selectivity of neopentyl glycol was studied.The results showed that the optimum condensation conditions were as follows:n(isobutyraldehyde)∶n(formaldehyde)=1∶1.05,triethylamine dosage 7%,the reaction temperature 60℃,and the reaction time 5 h.The optimal hydrogenation process conditions were as follows:the reaction pressure 4 MPa,the reaction temperature 95℃,the reaction time 4 h.Under above conditions,the yield of NPG was 94.6%,the selectivity of NPG was 94.7%.The amount of wastewater from the synthesis of neopentyl glycol was about one third of that from the traditional disproportionation method.