抗菌药物联合免疫球蛋白治疗中晚期肝病并发感染的临床疗效研究

Clinical efficacy of antibiotics combined with immunoglobulin in the treatment of advanced liver disease complicated with infection

目的:探究抗菌药物联合免疫球蛋白治疗中晚期肝病并发感染患者的临床疗效。方法:研究对象为2017年8月-2019年11月间在我院就诊的88例中晚期肝病并发感染的患者,随机将研究对象划分为仅抗菌药物治疗的对照组(44例)和抗菌药物联合免疫球蛋白治疗的观察组(44例)。比较两组的血清胆红素浓度(T-BIL)、凝血酶原时间(PT)、白蛋白(Alb)、谷丙转氨酶(ALT)、C反应蛋白(CRP)、降钙原(PCT)、白细胞介素6(IL-6)。结果:Child-Pugh得分小于10分的患者经治疗后,两组的肝功能指标(T-BIL、PT、Alb、ALT)和炎症因子水平(CRP、PCT、IL-6)差异不显著。Child-Pugh得分在10-15分的患者经治疗,观察组肝功能指标和炎症因子水平改善明显优于对照组,组间差异显著。结论:Child-Pugh得分在10-15分的中晚期肝病患者经抗菌药物联合免疫球蛋白治疗后,肝功能指标明显改善,炎症得到有效控制,建议推广。

Objective:To explore the clinical efficacy of antibiotics combined with immunoglobulin in the treatment of advanced liver disease complicated with infection.Methods:A total of 88 patients with advanced liver disease complicated with infection in our hospital from August 2017 to November 2019 were randomly divided into the control group(44 cases)treated with antibiotics only and the observation group(44 cases)treated with antibiotics combined with immunoglobulin.Serum bilirubin concentration(T-Bil),prothrombin time(PT),albumin(ALB),alanine aminotransferase(ALT),C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)were compared between the two groups.Results:After treatment,there was no significant difference in liver function indexes(T-Bil,Pt,ALB,ALT)and levels of inflammatory factors(CRP,PCT,IL-6)between the two groups after treatment.After treatment,the liver function indexes and inflammatory factor levels of the observation group were significantly better than those of the control group,and the difference between the two groups was significant.Conclusion:The child Pugh score of 10-15 points in patients with advanced liver disease after antibacterial drugs combined with immunoglobulin treatment,liver function indicators improved significantly,inflammation was effectively controlled,it is recommended to promote.