玉液汤为主的中药方治疗气阴两虚型老年糖尿病的临床分析

Clinical analysis of Yuye decoction based Chinese prescription for the treatment of senile diabetes mellitus with deficiency of Qi and Yin

目的观察探讨气阴两虚型老年糖尿病患者应用玉液汤为主的中药方治疗效果。方法选取2021-08-01-2023-08-01临沂市第三人民医院收治的气阴两虚型老年糖尿病患者88例作为研究对象,按随机数表法分为对照组和观察组,每组各44例。对照组给予二甲双胍,0.5 g/次,2次/d,观察组给予玉液汤为主的中药方联合盐酸二甲双胍片治疗,均治疗8周。观察2组治疗前后总有效率、空腹胰岛素(FINS)、空腹血糖(FPG)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)及不良反应。计量资料以X±S,计数资料以率n(%)表示,采用χ^(2)检验。结果观察组总有效率(87.4%)明显高于对照组(63.6%),差异有统计学意义,P=0.043。经单因素协方差分析治疗后2组FINS、FPG、IL-8、IL-6值比较,差异有统计学意义,F值分别为33.432、24.893、26.066和44.681,均P<0.001。观察组食欲不振、恶心呕吐、腹部不适、乏力头晕等不良反应(20.45%)与对照组(29.55%)比较,差异无统计学意义,P=0.900。结论玉液汤为主的中药方治疗气阴两虚型老年糖尿病患者疗效确切,能够减轻胰岛素抵抗,降低老年糖尿病患者血糖水平,改善微炎症状态。

Objective To observe and discuss the effect of Yuye decoction,a traditional Chinese medicine prescription,in the treatment of elderly diabetic patients with Qi-Yin deficiency.Methods A total of 88 elderly diabetic patients with Qi-yin deficiency treated in the Third People's Hospital of Linyi City from August 1,2021,to August 1,2023 were selected as the study objects and were divided into control group and observation group according to random number table,with 44 cases in each group.The control group was treated with metformin,0.5g/time,twice a day,the observation group was treated with Yuye decoction combined with metformin hydrochloride tablets,both groups were treated for 8 weeks.The total effective rate,fasting insulin(FINS),fasting blood glucose(FPG),interleukin-8(IL-8),interleukin-6(IL-6)and adverse reactions of two groups were observed before and after treatment.The measurement data were expressed as X±S,the rate was expressed by n(%),andχ^(2)test was adopted.Results The total effective rate of the observation group(87.4%)was significantly higher than that of the control group(63.6%)(P=0.043).Univariate co-variance analysis showed that the F values of FINS,FPG,IL-8 and IL-6 in two groups were 33.432,24.893,26.066 and 44.681,respectively after treatment,(P<0.001).There were significant statistical differences between the two groups(P<0.001).There was no statistical difference between the observation group(20.45%)and the control group(29.55%)in terms of adverse effects such as loss of appetite,nausea and vomiting,abdominal discomfort,fatigue and dizziness(P=0.900).Conclusion Traditional Chinese medicine based on Yuye Decoction is effective in treating elderly diabetic patients with Qi-yin deficiency,reducing blood sugar level and improving micro-inflammation in elderly patients with diabetes.