运脾通督推拿手法对急性轮状病毒感染性腹泻患儿机体免疫能力及胃肠激素水平影响

Study on the effects of activating the spleen and unblocking meridians and governor vessel massage therapy on immune capacity and gastrointestinal hormone levels in children with acute rotavirus infected diarrhea

目的探讨运脾通督推拿手法对急性轮状病毒感染性腹泻患儿机体免疫能力及胃肠激素水平的影响。方法选取2020-09-15-2021-10-15重庆市忠县人民医院收治的80例急性轮状病毒感染性腹泻患儿作为研究对象,采用随机数字表法分为对照组和观察组,各40例。对照组给予常规基础治疗及护理;观察组给予联合运脾通督推拿手法干预。对比2组患儿临床疗效、机体免疫能力、胃肠激素水平和不良反应发生情况。结果观察组干预后血管活性肠肽(VIP)、胃动素(MOT)、胃泌素(GAS)水平分别为(125.33±13.22)、(102.35±12.41)、(15.13±3.24)ng/L,均低于对照组的(148.62±12.85)、(125.44±10.33)、(19.25±3.01)ng/L,F值分别为7.991、9.045、5.901,均P<0.001。观察组干预后免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、T细胞淋巴亚群(CD4^(+)/CD8^(+))水平分别为(15.61±1.47)g/L、(1.53±0.15)g/L、(1.67±0.24),均高于对照组的(12.44±1.62)g/L、(1.27±0.16)g/L、(1.42±0.22),F值分别为9.165、7.500、4.853,均P<0.001。观察组治疗有效率高于对照组,Z=2.173,P=0.030。2组患儿治疗期间均未发生明显不良反应。结论运脾通督推拿手法对急性轮状病毒感染性腹泻患儿治疗效果确切,能够有效改善胃肠激素水平,提高机体免疫功能,安全性高。

Objective To study the effects of activating the spleen and massage therapy on immune capacity and gastrointestinal hormone levels of children with acute rotavirus-infected diarrhea.Methods A total of 80 children with acute rotavirus-infected diarrhea in Chongqing Zhongxian People’s Hospital from September 15,2020 to October 15,2021 were selected as the research objects.They were divided into two groups by random number table method.40 cases in the control group were given routine basic treatment and nursing,and the other 40 cases in the observation group were given combined massage therapy with activation of the spleen.The clinical efficacy,immune capacity,gastrointestinal hormone indexes and the incidence of adverse reactions were compared between the two groups.Results The levels of vasoactive intestinal peptide(VIP),motilin(MOT)and gastrin(GAS)in observation group were(125.33±13.22),(102.35±12.41)and(15.13±3.24)ng/L,respectively,lower than those in the control group(148.62±12.85),(125.44±10.33),(19.25±3.01)ng/L,F=7.991,9.045,5.901,all P<0.001.The levels of immunoglobulin G(IgG),immunoglobulin A(IgA)and T lymphocyte subsets(CD4^(+)/CD8^(+))in observation group were(15.61±1.47)g/L,(1.53±0.15)g/L,(1.67±0.24),respectively,higher than those in the control group(12.44±1.62)g/L,(1.27±0.16)g/L,(1.42±0.22),F=9.165,7.500,4.853,all P<0.001.The effective rate of observation group was higher than that of the control group(Z=2.173,P=0.030).There were no obvious adverse reactions in 2groups during treatment.Conclusion The manipulation of activation of the spleen and unblocking meridians and governor vessel massage therapy has a definite effect on children with acute rotavirus infected diarrhea,which can effectively and safely improve gastrointestinal hormone indexes and immune function.