大理古生村白族中老年人肌少症患病现状及相关因素分析

Prevalence and influencing factors of sarcopenia in the middle-aged and elderly of Bai ethnic group in Gusheng village,Dali city

目的调查大理古生村白族中老年人肌少症的患病率和探讨其相关因素,为后期制定相应的干预措施提供依据。方法于2018-11-17-2019-12-19采用现况调查方法共纳入180名大理古生村白族中老年人信息,采用清华同方人体成分分析仪,生物电阻抗法检测骨骼肌量等人体成分;使用弹簧握力器、5次起坐试验评估中老年人群的肌肉力量和躯体功能,并采集空腹静脉血完善相关实验室检查。根据2019年亚洲肌少症工作组(AWGS2019)诊断标准诊断肌少症,分为肌少症组24例,非肌少症组156例。比较2组的临床资料,采用多因素Logistic回归来分析肌少症的相关影响因素。结果肌少症总体患病率为13.33%(24/180),其中男性患病率为6.94%(5/72),女性患病率为17.59%(19/108)。肌少症组和非肌少症组受试者年龄、性别、体质量指数(BMI)、蛋白质、血红蛋白(HGB)、中性粒细胞/淋巴细胞比率(NLR)、胰岛素抵抗指数(HOMA-IR)、碱性磷酸酶(ALP)、尿素氮(BUN)、尿酸(UA)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、25羟基维生素D_(3)[25(OH)D_(3)]比较差异有统计学意义,均P<0.05。通过多因素Logistic回归分析后显示年龄(OR=1.157,95%CI:1.053~1.271,P=0.002)是肌少症发生的危险因素,BMI(OR=0.387,95%CI:0.257~0.582,P<0.001)、UA(OR=0.980,95%CI:0.968~0.992,P=0.001)是肌少症发生的保护因素。结论大理古生村白族中老年人肌少症患病率较高,年龄、BMI、UA与该地区肌少症的发生相关。

Objective To investigate the prevalence of sarcopenia and its related factors of the middle-oged and elderly Bai ethnic group in Gusheng village,Dali city,providing basis for the development of corresponding intervention measures.Methods From November 17,2018 to December 19,2019,data of 180 middle-aged and elderly Bai people in Gusheng village were collected by using the method of cross-sectional survey.The skeletal muscle mass and other body components were detected via bioresistance assay with body composition analyzer produced by Tsinghua Tongfang.The muscle strength and physical function of middle-aged and elderly people were assessed using a spring grip and five sit-up tests,and fasting venous blood was collected for laboratory examination.Sarcopenia was diagnosed according to the Asian Sarcopenia Working Group(AWGS2019)diagnostic criteria.The patients were divided into sarcopenia group(n=24)and non-sarcopenia group(n=156).The clinical data of the two groups were compared and the related factors of sarcopenia were analyzed by multivariate logistic regression.Results The overall prevalence of sarcopenia was 13.33%(24/180),with 6.94%(5/72)in males and 17.59%(19/108)in females.There were statistically significant difference in age,gender,body mass index(BMI),protein,hemoglobin(HGB),neutrophil/lymphocyte ratio(NLR),insulin resistance index(HOMA-IR),alkaline phosphatase(ALP),urea nitrogen(BUN),uric acid(UA),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and 25 hydroxyvitamin D_(3)[25(OH)D_(3)]between sarcopenia group and non-sarcopenia group of subjects,all P<0.05.Multivariate logistic regression analysis showed that age(OR=1.157,95%CI:1.053-1.271,P=0.002)was a risk factor of sarcopenia.BMI(OR=0.387,95%CI:0.257-0.582,P<0.001)and UA(OR=0.980,95%CI:0.968-0.992,P=0.001)were the protective factors of sarcopenia.Conclusions The prevalence rate of sarcopenia is high in the elderly and middle-aged people of Bai ethnic group in Gusheng village,Dali city.Age,BMI and uric acid are related to the occurrence of sarcopenia in this area.