子宫内膜样癌组织基质金属蛋白酶-19表达及其临床意义探讨

Expression and significance of MMP-19 in endometrioid carcinoma

目的检测子宫内膜样癌组织中基质金属蛋白酶-19(MMP-19)的表达,探讨其在不同临床病理特征中的表达差异,分析其与增殖指数Ki-67的关系。方法选取2020-01-01-2020-12-31南阳市第一人民医院确诊为子宫内膜样癌并行根治性手术治疗的69例患者作为观察组;选取同院同期增生期子宫内膜组织69例作为对照组。采用免疫组化法检测MMP-19和Ki-67的表达。采用SPSS 17.0对数据进行统计学分析,组间率对比行χ^(2)检验。结果观察组中MMP-19表达的阳性率为55.07%,高于对照组21.74%,差异有统计学意义,χ^(2)=16.205,P<0.001。MMP-19在不同浸润深度(χ^(2)=11.455,P=0.001)、颈管累犯(χ^(2)=10.195,P=0.001)、分化程度(χ^(2)=3.891,P=0.049)的分组中的表达差异有统计学意义。观察组中MMP-19与Ki67表达呈正相关性,r=0.67,P=0.010。结论子宫内膜样癌组织中MMP-19高表达,其与肿瘤的临床病理特征相关,MMP-19与Ki-67可能具有正向协同作用。

Objective To detect the expression of matrix metalloproteinase-19(MMP-19)in endometrioid carcinoma,explore the difference on different clinicopathological features,and analyze the relationship with proliferation index Ki-67(Ki67).Methods Sixty-nine patients with endometrioid carcinoma(treated with radical surgery)were selected as the observation group in Nanyang First People’s Hospital from January 1,2020 to December 31,2020.Sixty-nine cases with hyperplasia endometrial were selected as control group.The expressions of MMP-19 and Ki-67 were detected by immunohistochemistry method.Results The positive rate of MMP-19 was significantly higher in observation group(55.07%)than that in control group(21.74%)(χ^(2)=16.205,P<0.001).The expression of MMP-19 was significantly different in infiltration depth(χ^(2)=11.455,P=0.001),cervical canal recidivism(χ^(2)=10.195,P=0.001)and differentiation degree(χ^(2)=3.891,P=0.049).Positive correlation was found between MMP-19 and Ki-67 in the observation group(r=0.67,P=0.010).Conclusions The high expression of MMP-19 is higher in endometrioid tumor tissue,which is correlated with the pathological features.Positive synergistic effect is found between MMP-19 and Ki-67.