匹维溴铵联合复方嗜酸乳杆菌治疗腹泻型IBS效果及对炎性因子影响

Effect of pinaverium bromide combined with compound lactobacillus acidophilus in the treatment of diarrheal IBS and its influence on inflammatory factors

目的分析匹维溴铵联合复方嗜酸乳杆菌治疗腹泻型肠易激综合征(IBS)患者临床疗效及对炎性因子的影响,旨在发现更佳用药方式,缩短治疗周期,减少药物使用剂量,降低不良反应发生率。方法选择2018-12-01-2019-10-01固始县中医院收治的62例腹泻型IBS患者为研究对象,依据患者一般资料具有可比性的原则分为对照组和观察组,各31例。对照组使用匹维溴铵治疗,观察组在对照组基础上联用复方嗜酸乳杆菌治疗。对比分析两组患者临床治疗效果、炎性因子水平变化及不良反应发生情况。结果观察组总有效率为93.55%,高于对照组的67.74%,差异有统计学意义,P<0.05。治疗前,两组白细胞素-12(IL-12)、白细胞介素-8(IL-8)和血清γ-干扰素(IFN-γ)水平比较,差异无统计学意义,均P>0.05;治疗>1个月,观察组IL-12水平为(39.40±8.04)ng/L,低于对照组的(45.96±8.26)ng/L,t=3.169,P=0.002;IL-8水平为(3.25±0.81)ng/L,低于对照组的(3.80±0.88)ng/L,t=2.560,P=0.013;IFN-γ水平为(22.71±4.89)ng/L,低于对照组的(25.33±5.06)ng/L,t=2.073,P=0.043。观察组不良反应发生率为6.45%,低于对照组的12.90%,但差异无统计学意义,χ^(2)=0.185,P=0.668。结论匹维溴铵联合复方嗜酸乳杆菌治疗腹泻型IBS,可提升临床疗效,降低炎症因子水平,对患者病情恢复有积极影响。

Objective This study analyzed the clinical efficacy and inflammatory factors of pinaverium bromide combined with compound lactobacillus acidophilus on patients with diarrheal intestinal stress syndrome(IBS),aimed to discover better medication methods,shorten the treatment cycle,reduced the dosage of medications,and reduced the incidence of adverse reactions.Methods A total of 62 cases of diarrheal enteric irritability syndrome patients treated in the Gushi County Traditional Chinese Medicine Hospital of Henan Province from December 1,2018 to October 1,2019,according to the principle of comparability of the general information of the two groups’patients,they were divided into a control group and an observation group,with 31 cases in each group.The control group was given pinaverium bromide,and the observation group was treated with compound lactobacillus acidophilus based on the control group.The clinical curative effects and adverse reactions were compared between two groups.The changes of inflammatory factors in two groups were observed.Results The total effective rate of the observation group(93.55%)was higher than that of the control group(67.74%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of interleukin-12(IL-12),interleukin-8(IL-8)and interferon-γ(IFN-γ)between the two groups,all P>0.05.After 1 month of treatment,the level of IL-12 in the observation group was(39.40±8.04)ng/L,which was lower than that of the control group’s(45.96±8.26)ng/L,t=3.169,P=0.002.IL-8 level was(3.25±0.81)ng/L,lower than the control group’s(3.80±0.88)ng/L,t=2.560,P=0.013.IFN-γlevel was(22.71±4.89)ng/L,lower than the control group’s(25.33±5.06)ng/L,t=2.073,P=0.043.the incidence of adverse reactions in the observation group(6.45%)was slightly lower than that in the control group(12.90%),but the difference was not statistically significant(χ^(2)=0.185,P=0.668).Conclusion Pinaverium bromide combined with compound lactobacillus acidophilus in treatment of diarrhea-predominant IBS can increase clinical efficacy,decreases the levels of inflammatory factors,and has positive effect on the recovery of patients.