厦门市嘉莲街道体检人群血清同型半胱氨酸水平及影响因素分析

Analysis of serum homocysteine level and its influencing factors in physical examination population in Jialian Street of Xiamen City

目的本研究调查厦门市嘉莲街道≥40岁人群同型半胱氨酸(Hcy)水平并分析其影响因素,为预防高同型半胱氨酸血症(HHcy)做指导。方法选取厦门市嘉莲街道2015-07-05-2018-02-02参加体检的1591名≥40岁居民为研究对象,通过问卷和体格检查进行调查,内容包括一般资料、体质量指数(BMI)、空腹血糖(FBG)、血肌酐(Scr)、血尿素氮(BUN)、胆固醇、总胆固醇(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和Hcy等血液指标,分析Hcy升高的影响因素。结果居民平均Hcy值为(12.36±4.112)μmol/L,增高率为19.11%,其中男性Hcy平均值为(14.63±3.34)μmol/L,高于女性的(11.17±3.33)μmol/L,t=16.916,P<0.001。单因素分析结果显示,年龄(t=-13.435,P<0.001)、BMI(t=-5.571,P<0.001)、腰围(t=-7.900,P<0.001)、Scr(t=-12.398,P<0.001)、BUN(t=-9.317,P<0.001)、胆固醇(t=5.518,P<0.001)、TG(t=-2.005,P=0.045)、LDL(t=4.794,P<0.001)、HDL(t=3.862,P<0.001)、高血压病(χ2=94.883,P<0.001)和糖尿病(χ2=30.951,P<0.001)与Hcy升高有关联。多元非条件Logistic回归分析显示,性别(OR=0.375,95%CI为0.287~0.546,P<0.001)、年龄(OR=1.064,95%CI为1.046~1.082,P<0.001)、Scr(OR=1.046,95%CI为1.035~1.058,P<0.001)、高血压病(OR=1.742,95%CI为1.268~2.395,P<0.001)是Hcy升高的危险因素。结论男性、高龄、Scr升高和高血压是Hcy升高的危险因素。

Objective This study aimed to investigate the level of homocysteine(Hcy)in people≥40 years old in Jialian Street of Xiamen City,and to analyze its influencing factors to provide guidance for the prevention of hyperhomocysteinemia(HHcy).Methods A total of 1591 residents≥40 years old who participated in the physical examination from July 5,2015 to February 2,2018 in Jialian Street of Xiamen City were selected as the research subjects.The survey was conducted through questionnaires and physical examinations,including general information and body mass index(BMI),fasting blood glucose(FBG),blood creatinine(Scr),blood urea nitrogen(BUN),cholesterol,total cholesterol(TG),low density lipoprotein(LDL),high density lipoprotein(HDL)and Hcy,the factors affecting the increase of Hcy were analyzed.Results The average Hcy value of residents was(12.36±4.112)μmol/L,and the increase rate was 19.11%.The average value of male Hcy was(14.63±3.34)μmol/L,which was higher than that of women(11.17±3.33)μmol/L,t=16.916,P<0.001.The univariate analysis showed that age(t=-13.435,P<0.001),BMI(t=-5.571,P<0.001),waist circumference(t=-7.900,P<0.001),Scr(t=-12.398,P<0.001),BUN(t=-9.317,P<0.001),cholesterol(t=5.518,P<0.001)、TG(t=-2.005,P=0.045)、LDL(t=4.794,P<0.001)、HDL(t=3.862,P<0.001)、hypertension(χ2=94.883,P<0.001)and diabetes(χ2=30.951,P<0.001)were associated with elevated Hcy.Multivariate unconditional logistic regression analysis showed that gender(OR=0.375,95%CI:0.287-0.546,P<0.001),age(OR=1.064,95%CI:1.046-1.082,P<0.001),Scr(OR=1.046,95%CI:1.035-1.058,P<0.001),hypertension(OR=1.742,95%CI:1.268-2.395,P<0.001)were risk factors for elevated Hcy.Conclusion Male,advanced age,elevated Scr and hypertension are risk factors for elevated Hcy.