支原体耐药基因突变患儿175例临床特征分析报告

Analysis of disease characteristics of 175 patients with mutated mycoplasma resistance gene

目的本研究分析175例支原体耐药基因检测阳性(突变型)患儿发病特征,为耐药型支原体感染防治提供依据。方法选取2019-01-01-2019-12-31泰安市妇幼保健院收治的175例支原体耐药基因检测提示突变型的患儿为研究对象,于入院当天采集其咽拭子行MP-DNA及大环内酯类耐药基因检测,对其年龄、性别、发病季节、疾病分类和住院时间进行统计分析。结果175例MP突变型患儿男95例,女80例,男女之比为1.19∶1,年龄3个月~13岁,中位年龄(5.75±3.03)个月。性别构成差异无统计学意义,P>0.05。<3岁43例,占总突变型人数的24.57%,≥3~<6岁50例,占28.57%,≥6~13岁82例,占46.86%,年龄构成差异有统计学意义,χ2=14.824,P<0.05。支原体耐药基因检测突变型患儿全年均有发病,集中在8~11月份。春季(3~5月)32例,阳性构成比18.29%;夏季(6~8月)50例,阳性构成比28.57%;秋季(9~11月)68例,阳性构成比38.86%;冬季(12~2月)25例,阳性构成比14.28%;秋季患儿发病例数高于其他季节,χ2=25.526,P<0.001。支原体耐药基因检测为突变型的患儿,住院时间较长,平均住院时间为(10.78±3.28)d。80%患儿住院时间>7d,不同住院时间构成比比较,差异有统计学意义,χ2=63.000,P<0.05。支原体感染可导致多种疾病的发生,大叶性肺炎及节段性肺炎构成比之和达58.86%,与其他类型肺炎构成比比较,差异有统计学意义,χ2=5.491,P<0.05。结论支原体耐药基因检测突变型患儿全年均有发病,集中在8~11月,秋季患儿最多,多见于年长儿,住院时间较长。

Objective This study analyzed the morbidity characteristics of 175 children with mycoplasma drug-resistant gene detection positive(mutant type),and provided evidence for the prevention and treatment of drug-resistant mycoplasma infection.Methods A total of 175 cases of mycoplasma drug resistance gene detection with mutants in Taian Maternity and Child Health Hospital from January 1 to Decenber 31,2019 were selected as the research objects,and collected their throat swabs mycoplasma pneumonia(MP)DNA on the day of admission and macrolide resistance gene detection,statistical analyzed of its age,sex,season of onset,disease classification and length of hospital stay.Results Among the175 children with MP mutants,95 were males and 80 were females.The ratio of male to female was 1.19∶1,aged 3 months to 13 years,with a median age of(5.75±3.03)months.There was no statistically significant difference in gender composition,P>0.05.There were 43 cases of<3 years old,accounting for 24.57%of the total number of mutants,50 cases of≥3-<6 years old,accounting for 28.57%,82 cases of≥6-13 years old,accounting for 46.86%,and the difference in age composition was statistically significant,χ2=14.824,P<0.05.Patients with mycoplasma resistance gene mutation had the disease all year round,concentrated in August to November.In spring(March to May),there were 32 cases with the positive composition ratio 18.29%.In summer(June to August),there were 50 cases with the positive composition ratio 28.57%.In autumn(September to November),there were 68 cases with the positive composition ratio 38.86%.In winter(From December to February),there were 25 cases with the positive constituent ratio14.28%.The patients in autumn were more than those in other seasons,χ2=25.526,P<0.001.Children whose mycoplasma drug resistance gene was detected as a mutant had a longer hospital stay,with an average hospital stay of(10.78±3.28)days.80%of children were hospitalized for more than 7 days,comparing the composition ratio of different hospital stays,the difference was statistically significant,χ2=63.000,P<0.05.Mycoplasma infection can cause a variety of diseases.The sum of the composition ratio of lobar pneumonia and segmental pneumonia was 58.86%.Compared with other types of pneumonia,the difference was statistically significant,χ2=5.491,P<0.05.Conclusions Mycoplasma resistance gene detection mutant patients have disease all year round,concentrated in August to November.Most patients are in the autumn,the older children are more common,and the hospital stay is longer.