中药穴位贴敷疗法治疗嗜酸性粒细胞性支气管炎临床观察

Clinical observation on treatment of eosinophilic bronchitis with chinese herbal acupoint application therapy

目的吸入激素治疗是目前嗜酸性粒细胞性支气管炎(eosinophilic bronchitis,EB)的标准疗法,大多数患者预后良好,但部分患者停药后反复发作。本研究分析中药穴位贴敷疗法治疗EB疗效。方法选取2017-04-01-2018-10-01本院收治的64例EB患者为研究对象,按照组间年龄、性别、病程具有可比性的原则选择观察组与对照组,每组32例。对照组患者给予布地奈德干粉吸入剂,观察组患者在上述治疗基础上接受中药穴位贴敷治疗,均治疗8周。比较两组临床疗效、半年复发率、诱导痰嗜酸性粒细胞(eosinophils,Eos)分类、呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)、免疫球蛋白E(immunoglobulin E,IgE)、白介素-4(interleukin-4,IL-4)水平。结果观察组治疗有效率为93.75%,高于对照组的74.19%,χ~2=4.51,P=0.034;观察组半年复发率为9.38%,低于对照组的29.03%,χ~2=3.95,P=0.047。治疗后,观察组诱导痰Eos分类为(2.05±1.57)%,低于对照组的(3.89±2.24)%,t=4.311,P<0.001;FeNO水平为(22.52±5.36)ppb,低于对照组的(28.77±9.10)ppb,t=6.382,P<0.001;IgE水平为(153.64±20.29)g/L,低于对照组的(195.12±14.58)g/L,t=7.583,P=0.037;IL-4水平为(35.62±9.88)ng/L,低于对照组的(47.16±11.54)ng/L,t=8.293,P=0.042。结论中药穴位贴敷疗法治疗嗜酸粒细胞性支气管炎可明显缓解其临床症状,提高治疗有效率,降低复发率和炎症水平。

OBJECTIVE Inhaled hormone therapy is the current standard therapy for eosinophilic bronchitis(EB).Most patients have a good prognosis,but some patients have repeated attacks after stopping the drug.This study analyzes the efficacy of Chinese medicine acupoint application therapy in the treatment of EB.METHODS A total of 64 patients with EB admitted to our hospital from April 1,2017 to October 10,2018 were selected as the research subjects,the observation group and the control group were selected according to the principle of comparability of age,gender and disease course between the groups,32 cases in each group.The patients in the control group were given budesonide dry powder inhalation,and the patients in the observation group received acupoint application on the basis of the above treatment,and all were treated for 8 weeks.The clinical efficacy,recurrence rate of half a year,classification of eosinophils(Eos),fractional exhaled nitric oxide(FeNO),immunoglobulin E(IgE)and interleukin 4(interleukin 4,IL-4)level were compared between the two groups.RESULTS The effective rate of treatment in the observation group was 93.75%,which was higher than that of the control group 74.19%,χ~2=4.51,P=0.034.The recurrence rate in the observation group was 9.38%,which was lower than that of the control group 29.03%,χ~2=3.95,P=0.047.After treatment,the induced sputum eosinophils in the observation group was classified as(2.05±1.57)%,lower than that of the control group(3.89±2.24)%,t=4.311,P<0.001.FeNO level was(22.52±5.36)ppb,which was lower than that of the control group(28.77±9.10)ppb,t=6.382,P<0.001.IgE level was(153.64±20.29)g/L,which was lower than that of the control group(195.12±14.58)g/L,t=7.583 P=0.037.IL-4 level was(35.62±9.88)ng/L,which was lower than that of the control group(47.16±11.54)ng/L,t=8.293,P=0.042.CONCLUSION Acupoint application therapy of traditional Chinese medicine in the treatment of eosinophilic bronchitis could significantly relieve its clinical symptoms,improve the treatment efficiency,and reduce the recurrence rate and inflammation level.