柴芩清热汤治疗结核性胸膜炎发热临床观察

Clinical observation of conventional antituberculosis combined with Chaiqin Qingre Decoction in the treatment of tuberculous pleurisy patients with feve

目的常规西医治疗结核性胸膜炎以退热为主,预后效果并不理想,本研究分析柴芩清热汤对结核性胸膜炎发热患者辅助治疗的临床效果。方法选取2017-04-01-2018-03-31在鞍山市千山医院接受治疗的154例结核性胸膜炎发热患者作为研究对象,根据年龄和性别均衡原则将其分为观察组(77例)和对照组(77例)。对照组患者接受常规治疗,观察组患者在常规治疗基础上加用柴芩清热汤辅助治疗。比较两组患者治疗效果、不良反应情况、体温恢复正常时间以及住院时间。结果观察组患者治疗效率为93.51%,高于对照组的75.32%,差异有统计学意义,χ~2=9.674,P<0.001。观察组患者不良反应发生率为6.49%,与对照组的5.19%比较,差异无统计学意义,χ~2=0.118,P=0.862。观察组患者体温恢复正常时间为(4.41±2.35)d,少于对照组的(5.62±1.45)d,差异有统计学意义,t=3.845,P=0.001。观察组住院时间为(22.62±2.24)d,少于对照组的(30.41±3.12)d,差异有统计学意义,t=12.384,P<0.001;观察组胸腔积液时间为(10.11±2.89)d,少于对照组的(19.39±2.24)d,差异有统计学意义,t=22.271,P<0.001。观察组胸腔积液抽取量为(2493.43±257.39)mL,少于对照组的(5383.49±272.21)mL,差异有统计学意义,t=67.693,P<0.001。结论结核性胸膜炎发热患者在西医常规化疗基础上采用中药柴芩清热汤治疗效果良好,有利于缩短患者康复时间,不增加患者不良反应。

OBJECTIVE Conventional western medicine is mainly used to treat tuberculous pleurisy with antipyretic effect,and the prognosis is not ideal.This study analyzes the clinical effect of conventional antituberculosis combined with Chaiqin Qingre Decoction in adjuvant treatment of fever patients with tuberculous pleurisy patients with feve.METHODS Totaly of 154 patients with tuberculous pleurisy fever treated in Anshan Qianshan hospital from April 1,2017 to March 31,2018 were selected as the study subjects.According to different treatment methods,the patients were divided into observation group(77 cases)and control group(77 cases).The patients in the control group received routine treatment,while the patients in the observation group were treated with Chaiqin Qingre Decoction on the basis of routine treatment.The curative effect,adverse reactions,time of body temperature return to normal and length of hospital stay were compared between the two groups.RESULTS The therapeutic efficiency of the observation group was 93.51%,which was significantly higher than that of the control group(75.32%),with statistically significant difference,χ~2=9.674,P<0.001.The incidence of adverse reactions in the observation group was 6.49%,compared with 5.19%in the control group,with no statistically significant difference,χ~2=0.118,P=0.862.The recovery time of body temperature in the observation group was(4.41±2.35)d,which was less than(5.62±1.45)d in the control group,and the difference was statistically significant(t=3.845,P=0.001).The length of hospitalization in the observation group was(22.62±2.24)d,which was less than(30.41±3.12)d in the control group,and the difference was statistically significant(t=12.384,P<0.001).The duration of pleural effusion in the observation group was(10.11±2.89)d,less than that in the control group(19.39±2.24)d,with statistically significant difference(t=22.271,P<0.001).The amount of pleural effusion extracted in the observation group was(2493.43±257.39)ml,which was lower than that in the control group(5383.49±272.21)ml,and the difference was statistically significant(t=67.693,P<0.001).CONCLUSIONS The traditional Chinese medicine Chaiqin Qingre Decoction is effective in treating tuberculous pleurisy fever patients on the basis of conventional western medicine chemotherapy.It is beneficial to shorten the recovery time of patients without increasing adverse reactions.