仿生研究食品中铝的体内迁移分配及其生物利用率评价

Study of migration and distribution of aluminum from foods by in vitro biomimetic digestion and bioavailability assessment

目的重新界定食品铝进入人体后的形态(水溶态和单层脂质体亲和态),分别考察食品铝(粉条和千层饼)在胃肠中的溶出率及其迁入体循环系统的比率(生物利用率)。方法以"仿生胃肠消化、仿脂质体生物膜亲合吸附"为模型,对食品中铝在人体内的迁移分配进行了体外仿生消化研究。结果被测食品中铝在胃肠溶液中的溶出率为31.0%~42.5%,单层脂质体亲和态占比为69.4%~76.8%。结论食品铝在人体中具有与食品基质和体内环境相适应的生物可给性和生物利用率,不能以食品中铝的总量测定简单代替。因此,对于铝的每周耐受摄入量的确定应在同时考虑人体消化系统溶出率和食品铝的生物有效性的基础上制定。

Objective To redefine the form of food aluminum(water-soluble and monolayer liposome affinity)after entering the human body,and investigate the dissolution rate of food aluminum(vermicelli and lasagna)in the gastrointestinal tract and the ratio of its migration into the systemic circulation system(bioavailability).Methods The migration and distribution of aluminum from foods in human body were studied with an in vitro biomimetic digestion model.Digestion and absorption in the gastrointestinal tract were simulated by bionic gastrointestinal digestion and bionic biomembrane absorption with liposome.Results The dissolution rate of aluminum in the gastrointestinal tract was 31.0%~42.5%,in which,the rate of the affinity-liposome Al accounted for 69.4%~76.8%.Conclusion Aluminum has a bioaccessibility and bioavailability adapted to the food matrix and in vivo environment of human body,which could not be simply replaced by the total amount of aluminum in food.As a result,both the dissolution rate and the bioavailability of aluminum from food in the digestion system should be simultaneously taken into account for the establishment of the provisional tolerable weekly intake of aluminum.