天然产物通过诱导铁死亡改善肝纤维化的研究进展

Research progress of natural products ameliorate liver fibrosis by inducing ferroptosis

肝纤维化是多种慢性肝病发展为肝硬化和肝癌所必须经历的共同病理过程,在其发生、发展过程中受到多种细胞因子以及信号通路的调控。铁死亡是由铁过载、氧化还原稳态紊乱和脂质过氧化增加引起的一种新的细胞死亡调控模式,与肝纤维化密切相关。诱导肝星状细胞发生铁死亡可能是肝纤维化治疗的潜在靶标。许多天然产物可以诱导肝星状细胞发生铁死亡进而抑制肝纤维化的进展,因此越来越受到关注。然而,关于天然产物通过铁死亡途径调节肝纤维化的综述文章却相对较少。该文简述了天然产物通过铁死亡调控影响肝纤维化的干预机制及应用,重点探讨铁死亡与肝纤维化的关系,以及天然产物靶向铁死亡对肝纤维化的调控作用,旨在为天然产物治疗代谢性疾病和肝脏疾病的发展提供新的理论依据,也为将来的药物制取提供更多的备选策略。

Liver fibrosis(LF)is a common pathologic process that many chronic liver diseases develop into cirrhosis and hepatocellular carcinoma.Hepatic fibrosis is regulated by a variety of cytokines and signaling pathways during its occurrence and development.Ferroptosis is a new regulation mode of cell death caused by iron overload,REDOX homeostasis disorder and increased lipid peroxidation.A large number of studies have shown that ferroptosis is closely related to liver fibrosis and inducing ferroptosis in hepatic stellate cells may be a potential therapeutic target for liver fibrosis.Recent studies have shown that many natural products can induce ferroptosis in hepatic stellate cells and inhibit the progression of LF.The role of natural products is getting more and more attention.However,there are relatively few review articles on natural products regulating LF through the ferroptosis pathway.This paper briefly describes the intervention mechanism and application of natural products influencing LF through ferroptosis regulation.This paper focuses on the relationship between ferroptosis and LF,as well as the regulatory effect of natural products targeting ferroptosis on LF,hoping to provide a new theoretical basis for the development of natural products in the treatment of metabolic diseases and liver diseases,and also provide more alternative strategies for future drug production.