IGF2BP1在消化系统恶性肿瘤中的作用

Roles of IGF2BP1 in malignant tumors of digestive system

胰岛素样生长因子-2 mRNA结合蛋白(IGF2BPs)是一类高度保守的RNA结合蛋白家族,能够调控RNA的加工和代谢,并参与各种细胞的病理和生理过程。作为IGF2BPs的一个亚型,IGF2BP1通过与癌症相关靶标mRNA结合并增强其稳定性,促进肿瘤细胞增殖、生长、侵袭和化疗耐药,并与较差的预后相关。该文就IGF2BP1的结构、功能以及在消化系统恶性肿瘤进展与肿瘤化疗耐药中的作用和相关分子机制进行综述,以期为IGF2BP1的临床分子靶向治疗提供理论依据。

Insulin-like growth factor-2 m RNA binding proteins(IGF2BPs)are a family of highly conserved RNA binding proteins that regulate the processing and metabolism of RNA and participate in a variety of cellular pathological and physiological processes.As a subtype of IGF2BPs,IGF2BP1 promotes tumor cell proliferation,growth,invasion,and chemoresistance by binding to and enhancing the stability of cancer-related target mRNA,and is associated with a poorer prognosis.In this paper,we review the structure and function of IGF2BP1,as well as its role and related molecular mechanisms in the progression of malignant tumors and tumor chemotherapeutic resistance in the digestive system,in order to provide a theoretical basis for the development of a clinical molecular targeted therapy for IGF2BP1.