孕烷X受体介导的炎症反应在肠道和肝脏疾病中的作用

Roles of PXR-mediated inflammatory responses in intestinal and liver diseases

孕烷X受体(pregnane X receptor,PXR)是核受体超家族的成员之一,参与众多内源性和外源性的物质代谢,并与多种疾病如肝脏疾病、肾脏疾病、糖尿病和癌症等密切相关。PXR高表达于肠道和肝脏,由于肠道与外界相通,较易受外源物质刺激诱发炎症,而肝脏因其解剖位置和门静脉系统的存在,易继发于肠道产生炎症。PXR参与了肠道和肝脏炎症的发生、发展及治疗。本文简要综述PXR在肠道和肝脏炎症性疾病中的作用和临床意义。

Pregnane X receptor(PXR)is a member of nuclear receptor superfamily,involved in metabolism of multiple endogenous or exogenous substances and closely associated with a variety of diseases,such as liver diseases,kidney diseases,diabetes and cancer.PXR is highly expressed in intestine and liver.Since the intestine track is connected with the external environment,it is more susceptible to inflammation induced by exogenous substances.In sequence,the liver is susceptible to inflammation secondary to intestinal inflammation due to its anatomical position and the portal vein system.Studies have shown that PXR is involved in the onset,development and treatment of intestinal and hepatic inflammation.The current review briefly summarizes the role and clinical significance of PXR in inflammatory diseases of the intestine and liver.