1-磷酸鞘氨醇在肾脏纤维化中的作用及其调控

Contribution and regulation of sphingosine-1-phosphate signaling during the renal fibrosis

肾脏纤维化是原发或继发性肾脏病持续进展至终末期肾病的共同病理过程。1-磷酸鞘氨醇是一种具有生物活性的神经鞘脂类代谢物,参与组织纤维化的发生。研究发现,1-磷酸鞘氨醇在成纤维细胞转分化为肌成纤维细胞过程以及纤维化早期阶段炎症反应的诱导中发挥着关键作用。本文主要介绍1-磷酸鞘氨醇在肾脏纤维化中的作用及其调控,旨在更进一步认识肾脏纤维化发病机制,为肾脏纤维化疾病的预防及治疗提供新的靶向。

Renal fibrosis is a common pathological process in the various primary or secondary kidney diseases which can progress to the end-stage renal disease.Sphingosine-1-phosphate is a biologically active sphingolipid,which can participate in the occurrence of tissue fibrosis.Recent studies have found that sphingosine-1-phosphate plays a significant role in the transdifferentiation of fibroblasts to myofibroblasts and the induction of inflammatory responses during the early stages of fibrosis.The present article mainly introduces the contribution and regulation of sphingosine-1-phosphate signaling during the renal fibrosis,which will help us to further understand the pathogenesis of the renal fibrosis and provide us a new target to prevent and treat the renal fibrosis.