非编码RNA在血管平滑肌细胞钙化中的作用

Role of non-coding RNAs in vascular smooth muscle cell calcification

血管钙化是钙质物沉积在血管壁的一种病变,常引起血管壁僵硬度增加,是心脑血管疾病高发病率和高死亡率的重要因素之一,亦是动脉粥样硬化心血管事件、脑卒中和外周血管病的重要生物标志。血管钙化机制复杂且尚未完全阐明,近来研究发现非编码RNA在血管钙化过程中发挥重要作用。本文主要对参与血管平滑肌细胞钙化的主要非编码RNA类型进行综述,从成骨相关蛋白、钙化信号通路和细胞内Ca^(2+)改变等方面阐明非编码RNA在血管钙化中发挥的重要作用。

Vascular calcification,the deposition of calcium in the arterial wall,is often linked to increased stiffness of the vascular wall.Vascular calcification is one of the important factors for high morbidity and mortality of cardiovascular and cerebrovascular diseases,as well as an important biomarker in atherosclerotic cardiovascular events,stroke and peripheral vascular diseases.The mechanism of vascular calcification has not been fully elucidated.Recently,non-coding RNAs have been found to play an important role in the process of vascular calcification.In this paper,the main types of non-coding RNAs and their roles involved in vascular smooth muscle cell calcification are reviewed,including the changes of osteoblast-related proteins,calcification signaling pathways and intracellular Ca^(2+).