中医药调控线粒体介导的炎症防治2型糖尿病研究进展

Research Progress in the Treatment of Type 2 Diabetes by TCM Regulating Mitochondria-Mediated Inflammation Control

2型糖尿病(Type 2diabetes mellitus,T2DM)是由于能量摄入过多及消耗不足而引起的一种以代谢紊乱为主要临床表现的疾病,主要表现为胰岛β细胞功能障碍和胰岛素抵抗(Insulin resistance,IR)。现代医学中,T2DM口服治疗用药可能伴有肝肾功能损伤等不良反应。研究证明,中医药治疗T2DM疗效显著,具有多靶点、多组分、多通路的治疗优势。线粒体是细胞提供能量的主要细胞器,其通过氧化磷酸化(Oxidative phosphorylation,OXPHOS)反应产生ATP供能以维持细胞的功能平衡。而线粒体功能障碍、线粒体动力学异常、线粒体自噬受损与T2DM的发生密切相关。线粒体作为中医药治疗糖尿病的靶点已逐渐被证实,但缺乏中医药通过调节线粒体介导的炎症对T2DM影响的概述。因此该文综述了线粒体介导的炎症反应与T2DM的关系,以及中医药通过调控线粒体介导的炎症以干预T2DM的作用机制。

Type 2 diabetes mellitus(T2DM)is a metabolic disorder caused by excessive energy intake and insufficient consumption,which is mainly characterized by the dysfunction of isletβ-cell dysfunction and insulin resistance(insulin resistance,IR).In modern medicine,oral administration of T2DM may be accompanied by adverse reactions such as liver and kidney function injury.Studies have proved that traditional Chinese medicine has the significant superiority of multi-target,multi-component and multi-pathway.Mitochondria are the main organelles for cells to provide energy.They supply energy to ATP through oxidative phosphorylation(OXPHOS)reaction to maintain the functional balance of cells.There are closely related to the occurrence of T2DM between mitochondrial dysfunction,abnormal mitochondrial dynamics and impaired mitochondrial autophagy.Mitochondria has been gradually confirmed as the target of traditional Chinese medicine in the treatment of diabetes,but there is a lack of an overview of the effects of traditional Chinese medicine on T2DM by regulating mitochondrial-mediated inflammation.Therefore,this paper reviews the relationship between mitochondrial-mediated inflammation and T2DM,and the mechanism of traditional Chinese medicine to interfere with T2DM by regulating mitochondrial-mediated inflammation.