清法在重症肺炎中的临床应用及作用机制

Clinical Application and Mechanism of Clearing Therapy in Severe Pneumonia

重症肺炎是严重危害公众健康的重大疾病,死亡率高,社会负担重。中医清法是重症肺炎常见的中医药治疗方法,但清法包含的具体治疗措施较多,且尚无研究对清法治疗重症肺炎的机制进行系统梳理。本文总结了清法在重症肺炎治疗中的具体应用和效应机制,指出了临床上常见的治疗重症肺炎的清法主要包括了清宣法、清化法、清下法、清补法,其机制与调节炎症因子、调节免疫失衡、调节肺肠轴、抗氧化应激、协同抑菌等有关。本文从清法治疗重症肺炎的临床应用和作用机制的角度出发,认为清法在辅助治疗重症肺炎中体现出了较好的临床疗效和优势,但中医药辨证论治的运用和机制研究仍较少。今后当创建基于中医辨证论治的中西医结合治疗方案和疗效评价体系,推进中医药治疗急危重症的发展。

Severe pneumonia is a major disease that seriously endangers public health,with high mortality and heavy social burden.Despite the emergence of new drugs and strategies in treatment,the mortality of severe pneumonia remains high.Clearing therapy has achieved good application effect in severe pneumonia,mainly including clearing away propaganda,clearing away heat,clearing away purgation and clearing tonifying therapy.Its mechanism is related to regulating inflammatory factors,regulating immune imbalance,regulating lung and intestine axis,resisting oxidative stress,cooperating with bacteriostasis,etc.This paper summarizes the clinical application and related research progress of the mechanism of clearing therapy in the treatment of severe pneumonia,with a view to providing reference for clinical application of clearing therapy in the treatment of severe pneumonia and providing a demonstration for the treatment of critically ill patients with traditional Chinese medicine(TCM).