基于肠道微生态探讨针灸“从肠治皮”干预慢性荨麻疹的机制研究

Study on the Mechanism of Acupuncture"Treating Skin from Intestine"in the Intervention of Chronic Urticaria Based on Gut Microbiome

慢性荨麻疹(Chronic urticaria,CU)是一种涉及自身免疫及变态反应的常见皮肤病,给患者和社会带来了沉重负担。中医“肺合大肠,大肠者,皮其应”理论早已表明肠腑功能与皮部存在紧密的生理病理联系,随着现代医学理论“肠-皮轴”的提出,肠道微生态与CU相关性也逐渐成为研究的热点,纠正肠道微生态失调将是临床治疗CU的新趋势。针灸具有良性调节肠道微生态的效应作用,且临床治疗CU疗效肯定。因此,本文将近年来肠道微生态与CU之间的研究进展加以总结,探讨针灸通过调节肠道微生态治疗CU的可行性,围绕“从肠治皮”的角度为针灸治疗CU的机制研究提供新思路。

Chronic Urticaria(CU)is a common skin disease involving autoimmunity and allergies,which brings a heavy burden to patients and society.The theory of traditional Chinese medicine"the Lung is combined with the Large Intestine,and the symptoms of large intestine can be reflected from the skin"has long shown that there is a close physiological and pathological relationship between the function of the Large Intestine and the skin.With the modern advancement of the"gut-skin axis"theory,the correlation between gut microbiome and CU has gradually become an emerging focus of research.Adjusting the imbalance of gut microbiome would be a new trend in the clinical treatment of CU.Acupuncture has a beneficial effect of regulating the gut microbiome,and the definite curative effect on CU.Therefore,this article summarized the research progress between the gut microbiome and CU in recent years,in order to discuss the feasibility of acupuncture to treat CU by regulating the gut microbiome,and provide a new idea for the mechanism research of acupuncture in the treatment of CU from the perspective of"treating skin from intestine".