摘要
慢性荨麻疹(Chronic urticaria,CU)是一种涉及自身免疫及变态反应的常见皮肤病,给患者和社会带来了沉重负担。中医“肺合大肠,大肠者,皮其应”理论早已表明肠腑功能与皮部存在紧密的生理病理联系,随着现代医学理论“肠-皮轴”的提出,肠道微生态与CU相关性也逐渐成为研究的热点,纠正肠道微生态失调将是临床治疗CU的新趋势。针灸具有良性调节肠道微生态的效应作用,且临床治疗CU疗效肯定。因此,本文将近年来肠道微生态与CU之间的研究进展加以总结,探讨针灸通过调节肠道微生态治疗CU的可行性,围绕“从肠治皮”的角度为针灸治疗CU的机制研究提供新思路。
Chronic Urticaria(CU)is a common skin disease involving autoimmunity and allergies,which brings a heavy burden to patients and society.The theory of traditional Chinese medicine"the Lung is combined with the Large Intestine,and the symptoms of large intestine can be reflected from the skin"has long shown that there is a close physiological and pathological relationship between the function of the Large Intestine and the skin.With the modern advancement of the"gut-skin axis"theory,the correlation between gut microbiome and CU has gradually become an emerging focus of research.Adjusting the imbalance of gut microbiome would be a new trend in the clinical treatment of CU.Acupuncture has a beneficial effect of regulating the gut microbiome,and the definite curative effect on CU.Therefore,this article summarized the research progress between the gut microbiome and CU in recent years,in order to discuss the feasibility of acupuncture to treat CU by regulating the gut microbiome,and provide a new idea for the mechanism research of acupuncture in the treatment of CU from the perspective of"treating skin from intestine".
作者
肖显俊
石云舟
曹炜
姚俊鹏
邹子豪
胡笑燊
钟冬灵
金荣疆
李瑛
陈明岭
李涓
Xiao Xianjun;Shi Yunzhou;Cao Wei;Yao Junpeng;Zou Zihao;Hu Xiaoshen;Zhong Dongling;Jin Rongjiang;Li Ying;Chen Mingling;Li Juan(School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Acupuncture and Tuina School,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Graduate School,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Dermatological Department,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第6期2174-2179,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年基金项目(82205283):基于“从肠治皮”理论的针刺调控SCFAs介导Syk/BTK轴缓解荨麻疹症状的机制研究,负责人:肖显俊
国家自然科学基金委员会青年基金项目(82105026):基于外泌体miRNA-221调控PI3K/Akt/Ca2+轴探讨针刺治疗荨麻疹的效应机制,负责人:石云舟
中国博士后科学基金(2022MD723719):肠源性丁酸促进表皮细胞增殖分化:电针改善表皮屏障的效应机制研究,负责人:肖显俊。
关键词
慢性荨麻疹
肠道微生态
针灸
肠-皮轴
从肠治皮
Chronic urticaria
Gut microbiome
Acupuncture
Gut-skin axis
Treating skin from intestine