基于中西医临床病症特点的病毒性心肌炎动物模型分析

Animal Model Analysis of Viral Myocarditis Based on the Clinical Characteristics of Traditional Chinese and Western Medicine

目的病毒性心肌炎(Viral myocarditis,VMC)是指由柯萨奇病毒、腺体病毒、孤儿病毒等多种病毒感染引起的一种炎症性心血管系统疾病,但发病机制尚不明确,故复制出新的动物模型是研究其机制的重要方法。方法迄今为止,通过查阅与病毒性心肌炎动物模型相关的国内外文献,并根据中西医临床病症特点对纳入动物模型的造模方法、动物的种类、造模机制、优缺点以及临床吻合度进行归纳、总结和评价。结果根据对纳入模型的统计,结果发现其病毒CVB3诱导的VMC动物模型最为多见,病毒性心肌炎的模型复制主要以西医指标为主,与中医证型吻合度较低。此外,目前尚未有公认含有中医证型的模型复制方法,且造模过程缺乏中医辨证思维,故这将对中医的研究造成一定的局限性。结论因此,本文提出了病毒性心肌炎动物模型的改进方法,以及完善对动物模型体系的评价,使病毒性心肌炎动物模型的构建更接近临床,为病毒性心肌炎的中药疗效判定及药理作用的探讨提供了理论基础,也为后续研究病毒性心肌炎的防治措施、发病机制提供理论依据,以期建立与中西医临床特点更加吻合的病毒性心肌炎模型,以及规范VMC动物模型的评价标准,是病毒性心肌炎动物模型未来研究的重点。

Objective Viral myocarditis(VMC)is an inflammatory cardiovascular disease caused by Coxsackievirus,glandular virus,orphan virus and other viral infections.However,the pathogenesis of VMC is still unclear,so itis important to replicate a new animal model to study its mechanism.Methods So FAR,THE domestic and foreign literatures related to animal models of viral myocarditis were reviewed,and the modeling methods,types of animals,modeling mechanism,advantages and disadvantages,and clinical anastomosis of the included animal models were summarized and evaluated according to the characteristics of clinical symptoms of Chinese and western medicine.Results According to the statistics of the included models,it was found that the animal model of VMC induced by CVB3 was the most common.The model replication of viral myocarditis was mainly based on western medicine indicators,and the coincidence with traditional Chinese medicine syndrome type was low.In addition,there is no recognized model replication method with TCM syndrome types,and the model making process lacks TCM syndrome differentiation thinking,so it will cause certain limitations to the research of TCM.Conclusion Therefore,this article puts forward the improved method of animal model of viral myocarditis,and perfect the evaluation for animal model system,make the animal model of viral myocarditis build closer to clinical,for viral myocarditis curative effect of traditional Chinese medicines to judge and the discussion of pharmacological effects,provides a theoretical basis for the follow-up study of viral myocarditis provide theoretical basis for the prevention and control measures,the pathogenesis,in order to establish a combination model of viral myocarditis highly consistent with the clinical characteristics of traditional Chinese and Western medicine,so as to standardize the evaluation criteria of animal models of VMC,is the focus of future research on animal models of viral myocarditis.