青少年抑郁障碍患者皮质醇水平与中医证候相关性研究

A Study on the Correlation Between Cortisol Levels and TCM syndrome distribution in Adolescents with Depressive Disorder

目的分析青少年抑郁障碍患者血浆皮质醇(Cortisol,COR)分泌水平与中医证型间的相关性。方法本研究纳入分析2021年4月—2022年4月浙江省立同德医院的住院青少年抑郁患者60例的血浆皮质醇水平。抽取检测患者同日8:00、16:00、24:00的血浆皮质醇,并由两名精神专科的中医医师对患者的中医证型进行诊断,探讨抑郁症障碍患者的中医证型与血浆皮质醇水平之间是否存在相关性。数据统计分析选择SPSS 25.0软件。结果本研究纳入的60例抑郁障碍患者,表现出更高血浆皮质醇水平的中医证型为肝郁气滞证、心脾两虚证;抑郁障碍患者血浆皮质醇水平与中医证型具有相关性(P<0.05)。结论多数抑郁障碍患者血浆皮质醇检测提示皮质醇水平升高,且患者血浆皮质醇水平与中医证型分布之间存在相关性,肝郁气滞证、心脾两虚证的抑郁患者皮质醇升高更为明显。

Objective To analyze the correlation between plasma cortisol secretion levels and TCM syndrome in adolescents with depressive disorder.Methods This study included and analyzed the plasma cortisol levels of 60 depressed adolescents hospitalized in Zhejiang Tongde Hospital from April 2021 to April 2022.The plasma cortisol of the patients was collected and tested at 8:00,16:00 and 24:00 on the same day,and two TCM physicians from psychiatric specialties diagnosed the TCM type of the patient,and whether there was a correlation between the TCM symptom type and plasma cortisol level in patients with depression disorders.SPSS 25.0 software was selected for statistical analysis of data.Results The 60 patients with depressive disorders included in this study,and the TCM symptoms showed higher plasma cortisol levels,including liver depression and stagnation,and cardio-spleen deficiency.The plasma cortisol level of patients with depressive disorder was correlated with the TCM type(P<0.05).Conclusion The plasma cortisol test of most patients with depressive disorders showed that COR was elevated,and there was a correlation between the plasma cortisol level of patients and the distribution of TCM symptoms,and the increase in cortisol was more obvious in depressed patients with liver depression and spleen deficiency.