支气管哮喘中医证候与炎症表型、生存质量的相关性研究

Correlation Study Between TCM Syndromes of Bronchial Asthma and Inflammatory Phenotype and Quality of Life

目的探讨哮喘中医证候与炎症表型、生存质量的相关性。方法采用前瞻性横断面研究,收集2018年11月-2020年12月于河南中医药大学第一附属医院就诊的哮喘患者进行辨证分型,检测诱导痰确定炎症表型,填写相关生存质量问卷。用SPSS 25.0建立数据库,运用单因素分析、logistic回归分析及Spearman相关分析进行统计,3种方法中有2种具有统计学意义的被筛选为相关因素。结果收集哮喘患者390例,信息完整、符合研究标准184例患者。结果显示:外寒内饮证与性别、年龄、吸烟史、EA,风痰阻肺证与过敏性鼻炎、年龄、EA,痰热壅肺证与EA、NA,肺气虚证与EA,肺脾气虚证与EA、NA、ACQ-7评分,肺肾气虚证与年龄、咳喘VAS评分、ACQ-7评分、LCQ评分、CSS评分,肺肾阳虚证与ACQ-7评分、AQLQ评分分别具有相关性(P<0.05)。结论哮喘中医证候与炎症表型具有相关性,外寒内饮证、风痰阻肺证、肺气虚证患者多表现为EA;痰热壅肺证、肺脾气虚证患者多表现为EA、NA;哮喘中医证候与生存质量具有相关性,ACQ-7评分、咳喘VAS评分、LCQ评分、CSS评分、AQLQ评分可作为哮喘症状控制情况、生存质量水平的评估工具。

Objective To explore the relationship between TCM syndromes of asthma,inflammatory phenotypes and quality of life.Methods A prospective cross-sectional study was conducted to collect asthma patients treated in the First Affiliated Hospital of Henan University of traditional Chinese medicine from November 2018 to December 2020 for syndrome differentiation,detect induced sputum,determine inflammatory phenotype,and fill in relevant quality of life questionnaires.The database was established with SPSS25.0,and statistics were performed using single factor analysis,logistic regression analysis,and Spearman correlation analysis.Of the three methods,two statistically significant were screened as related factors.Results Collected 390 asthma patients,184 patients with complete information and meeting the research criteria.The results showed that external cold and internal drinking syndrome was related to gender,age,smoking history,EA,wind phlegm obstructing lung syndrome was related to allergic rhinitis,age,EA,phlegm heat obstructing lung syndrome was related to EA,lung qi deficiency syndrome was related to EA,lung spleen qi deficiency syndrome was related to EA,NA,ACQ-7 score,lung and kidney qi deficiency syndrome was related to age,cough and asthma VAS score,ACQ-7 score,LCQ score,CSS score,Lung kidney yang deficiency syndrome was related to ACQ-7 score and AQLQ score(P<0.05).Conclusion TCM Syndromes of asthma are correlated with inflammatory phenotype.EA is the most common manifestation in patients with external cold and internal drinking syndrome,wind phlegm blocking lung syndrome and lung qi deficiency syndrome;EA and NA are the most common manifestations in patients with phlegm heat blocking lung syndrome and lung spleen qi deficiency syndrome;TCM Syndromes of asthma are correlated with quality of life.ACQ-7 score,cough and asthma VAS score,LCQ score,CSS score and AQLQ score can be used as evaluation tools for asthma symptom control and quality of life.