基于数据挖掘的金陵医派张简斋治疗湿证用药规律探析

Study on Medication Rule of Treating Diseases Caused by Dampness Pathogens from Jingling's Famous Doctor Zhang Jianzhai Based on Data Mining

目的探讨金陵医派张简斋治疗湿证相关内科疾病的用药规律,为中医临床用药提供依据。方法收录张简斋临床治疗湿证相关内科疾病的有效医案,利用Microsoft Excel 2016,建立方药数据库,采用中医传承计算平台(V3.0)、IBM SPSS Modeler 18.0和SPSS Statistics 26.0软件分析其临床用药经验。结果最终纳入有效医案110首方剂,统计中医内科疾病诊断30种;疾病辨证以湿热证最多;使用高频次药物为半夏、茯苓、陈皮、甘草等;用药四气以温、寒、平为主;用药五味以苦、甘、辛为主;用药归经以脾、肺、胃经居多;关联分析得到18条关联药物,核心组合为“半夏-茯苓-陈皮-甘草”,聚类分析得到5组多味药物聚合组。结论张简斋治疗湿证相关内科疾病以二陈汤为基础方,以燥湿渗湿、健脾宁心、宣畅气机为基本治疗原则,并辨证论治,对证用药。

Objective To analyse the medication rule of treating traditional Chinese medicine internal diseases caused by dampness pathogens from Jingling′s famous doctor Zhang Jianzhai and provide references for clinical practices.Methods Collect all the medical records about internal diseases with etiology of dampness,use Microsoft Excel 2016 to establish relevant databases,then analyse Zhang Jianzhai′s clinical medication experience by the traditional Chinese medicine inheritance computing platform(V3.0),SPSS Statistics 26.0 and IBM SPSS Modeler 18.0 software.Results A total of 110 prescriptions in line with the rules were included,which contained 30 kinds of Chinese medicine internal disease diagnosis.The most often appeared traditional Chinese medicine differentiation was humid-heat syndrome.The most frequently used drugs were Banxia,Fuling,Chenpi and Gancao ect..The most herbs had warm nature,followed by cold nature and mild nature,and the tastes were mainly bitter,sweet and pungent.The meridian tropisms were mainly spleen,lung,stomach.Through the correlation analysis,a total of 18 related data were obtained,and the core combination was"Banxia-Fuling-Chenpi-Gancao".The cluster analysis of core drugs showed that there were 5 groups of multi-drug aggregation group.Conclusion Zhang Jianzhai is good at using Erchen decoction as the basic prescription in treating internal diseases caused by dampness pathogens.The basic treatment principles are drying and permeating dampness,strengthening spleen and quieting the mind,dredging functional activity of qi.Zhang Jianzhai follows the principle of syndrome differentiation and prescribes according to different Chinese medicine syndromes.